The role of the extracellular matrix in primary myelofibrosis
| Autor: | Katya Ravid, Shinobu Matsuura, Seng Kah Ng, Orly Leiva, Alessandra Balduini, S Chitalia |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Review Hematology Biology medicine.disease Extracellular Matrix Cell biology Extracellular matrix 03 medical and health sciences Leukemia Haematopoiesis 030104 developmental biology medicine.anatomical_structure Oncology Primary Myelofibrosis Fibrosis Mutation medicine Humans Bone marrow Stem cell Myelofibrosis Myeloproliferative neoplasm |
| Zdroj: | Blood Cancer Journal |
| ISSN: | 2044-5385 |
| DOI: | 10.1038/bcj.2017.6 |
| Popis: | Primary myelofibrosis (PMF) is a myeloproliferative neoplasm that arises from clonal proliferation of hematopoietic stem cells and leads to progressive bone marrow (BM) fibrosis. While cellular mutations involved in the development of PMF have been heavily investigated, noteworthy is the important role the extracellular matrix (ECM) plays in the progression of BM fibrosis. This review surveys ECM proteins contributors of PMF, and highlights how better understanding of the control of the ECM within the BM niche may lead to combined therapeutic options in PMF. |
| Databáze: | OpenAIRE |
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