Mode of Bioenergetic Metabolism during B Cell Differentiation in the Intestine Determines the Distinct Requirement for Vitamin B1
| Autor: | Kurara Honda, Shiori Shikata, Hidehiko Suzuki, Makoto Suematsu, Hiroshi Kiyono, Mitsutoshi Setou, Taichi Wake, Eri Hashimoto, Jun Kunisawa, Yuji Suzuki, Takahiro Nagatake, Yuki Sugiura, Risa Nagasawa |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Vitamin
medicine.medical_specialty Cellular differentiation Citric Acid Cycle Plasma Cells Naive B cell Biology Lymphocyte Activation Antibodies Lymphocyte Depletion General Biochemistry Genetics and Molecular Biology Mice Peyer's Patches chemistry.chemical_compound Vitamin B Deficiency Antigen Internal medicine medicine Animals Cell Lineage Glycolysis Thiamine Intestinal Mucosa Immunity Mucosal lcsh:QH301-705.5 B cell B-Lymphocytes Mice Inbred BALB C Cell Differentiation Metabolism Immunity Humoral Immunoglobulin A Cell biology Citric acid cycle medicine.anatomical_structure Endocrinology Immunoglobulin M lcsh:Biology (General) chemistry Female Lymph Nodes |
| Zdroj: | Cell Reports, Vol 13, Iss 1, Pp 122-131 (2015) |
| ISSN: | 2211-1247 |
| Popis: | Bioenergetic metabolism varies during cell differentiation, but details of B cell metabolism remain unclear. Here, we show the metabolic changes during B cell differentiation in the intestine, where B cells differentiate into IgA(+) plasma cells (PCs). Naive B cells in the Peyer's patches (PPs) and IgA(+) PCs in the intestinal lamina propria (iLP) both used the tricarboxylic acid (TCA) cycle, but only IgA(+) PCs underwent glycolysis. These metabolic differences reflected their dependencies on vitamin B1, an essential cofactor for the TCA cycle. Indeed, the diminished activity of the TCA cycle after dietary vitamin B1 depletion decreased the number of naive B cells in PPs without affecting IgA(+) PCs in the iLP. The maintenance of naive B cells by dietary vitamin B1 was required to induce-but not maintain-intestinal IgA responses against oral antigens. These findings reveal the diet-mediated maintenance of B cell immunometabolism in organized and diffuse intestinal tissues. |
| Databáze: | OpenAIRE |
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