Musculoskeletal Ultrasound and the Assessment of Disease Activity in Juvenile Idiopathic Arthritis

Autor: Patricia, Vega-Fernandez, Edward J, Oberle, Michael, Henrickson, Jennifer, Huggins, Sampath, Prahalad, Amy, Cassedy, Johannes, Roth, Tracy V, Ting
Rok vydání: 2023
Předmět:
Zdroj: Arthritis Care & Research.
ISSN: 2151-4658
2151-464X
DOI: 10.1002/acr.25073
Popis: To determine the frequency of subclinical synovitis on musculoskeletal ultrasound (MSUS) in Juvenile Idiopathic Arthritis (JIA) and correlate patient- and provider-reported outcome measures with MSUS synovitis.JIA patients with an active joint count (AJC)4 underwent a 42-joint MSUS performed at baseline and 3 months. B-mode and Power Doppler images were obtained and scored (range 0-3) for each of the 42-joints. Outcomes evaluated included: physician global assessment (PhGA), patient global assessment (PGA), patient pain, Child Health Assessment Questionnaire (CHAQ), and AJC. Subclinical synovitis was defined as synovitis detected by MSUS only. Generalized Estimation Equations were used to test the relationship between clinical arthritis (positive/negative) and subclinical synovitis (positive/negative). Spearman's correlation coefficients (rIn 30 patients subclinical synovitis was detected in 30% of joints. Clinical arthritis of the fingers, wrists, and knee joints was significantly associated with MSUS synovitis of these joints. PGA and the CHAQ had a moderate (rs: 0.44, p=0.014) to weak (rs: 0.37, p=0.045) correlation with MSUS synovitis. There was a statistically significant strong correlation between MSUS synovitis and PhGA (rs: 0.61, p=0.001), but weak correlation with AJC (rs: 0.37, p=0.048) at the follow-up visit.Subclinical synovitis was commonly observed in this cohort of JIA patients. The fair to moderate correlation of MSUS synovitis with patient- and provider-reported outcomes suggests that MSUS assesses a different, possibly more objective, domain not determined by traditional JIA outcome measurements. This article is protected by copyright. All rights reserved.
Databáze: OpenAIRE
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