Age-related changes of corneal endothelial cell in healthy Chinese tree shrew measured by non-contact specular microscope
| Autor: | Ya-Qi Huang, Xiao-Cheng Liu, Yu-Run Miao, De-Xuan Kuang, Min Wu, Jie-Jie Dai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Endothelium genetic structures Coefficient of variation Tree shrew lcsh:Ophthalmology Ophthalmology Cornea Age related cornea Chinese tree shrew (Tupaia belangeri chinensis) medicine specular microscope business.industry eye diseases endothelial cells Endothelial cell density medicine.anatomical_structure Basic Research age lcsh:RE1-994 SPECULAR MICROSCOPY Corneal endothelial cell sense organs business |
| Zdroj: | International Journal of Ophthalmology, Vol 10, Iss 12, Pp 1798-1804 (2017) |
| ISSN: | 2227-4898 2222-3959 |
| Popis: | AIM: To determine the impact of age on the morphology of endothelial cells and central corneal thickness (CCT) in Chinese tree shrew. METHODS: One-hundred and twenty eyes of 60 healthy Chinese tree shrews were studied. Based on age, the tree shrews were divided into four groups. After general anesthesia, the images of endothelium were acquired using non-contact specular microscope Topcon 3000P. Eight parameters of corneal endothelial cells were measured by built-in software, including CCT, endothelial cell density (ECD), percent hexagonality (HG%), coefficient of variability (CV), size of minimal cell (Smin), size of maximal cell (Smax), average cells size (Savg) and size standard deviation (Ssd). Data were analyzed using STATA software. The differences of eight parameters among groups and correlations with age were analyzed. RESULTS: In all studied animals, the average CCT was 249.6±20.29 μm (202-301 μm), ECD was 3080.72± 460.76 cells/mm2 (1239.6-4047.6 cells/mm2) and CV was 29.10±7.60 (13.6-54.6). CV was significantly different among different groups (P |
| Databáze: | OpenAIRE |
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