The gastrin gene promoter is regulated by p73 isoforms in tumor cells
| Autor: | M C Kelly, Anna E. Vilgelm, Timothy C. Wang, Alexander Zaika, K Tomkova, Wael El-Rifai |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Gene isoform
Cancer Research Lung Neoplasms Tumor suppressor gene Biology medicine.disease_cause Mice Downregulation and upregulation Stomach Neoplasms Transcription (biology) Cell Line Tumor Gastrins Genetics medicine Animals Humans Protein Isoforms RNA Messenger Promoter Regions Genetic skin and connective tissue diseases neoplasms Molecular Biology Transcription factor Gastrin Messenger RNA Tumor Suppressor Proteins digestive oral and skin physiology Nuclear Proteins Tumor Protein p73 DNA-Binding Proteins Cancer research Carcinogenesis hormones hormone substitutes and hormone antagonists |
| Zdroj: | Oncogene. 25:6032-6036 |
| ISSN: | 1476-5594 0950-9232 |
| DOI: | 10.1038/sj.onc.1209610 |
| Popis: | p73, a new p53 family member, is a transcription factor that is increasingly recognized in cancer research as an important player in tumorigenesis as well as in chemotherapeutic drug sensitivity. Despite the substantial structural and functional similarities to p53, accumulating evidence suggests that p53 and p73 may differently regulate their transcriptional targets. In this study, we have investigated the role of p73 in regulation of the gastrin gene promoter. Gastrin is a peptide hormone and an important factor in determining the progression of a number of human malignancies. Our results show that p73 can bind to the gastrin promoter. This leads to transcriptional upregulation of gastrin mRNA. We also found that the levels of gastrin and p73 transcripts correlate in primary gastric tumors. Taken together, our results demonstrate a novel mechanism for regulation of gastrin gene transcription and support a concept that p53 and p73 may have different biological roles in tumors. |
| Databáze: | OpenAIRE |
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