General Principles of Pharmaceutical Solid Polymorphism. A Supramolecular Perspective
| Autor: | Adam J. Matzger, Naír Rodríguez-Hornedo, Christopher P. Price, Adivaraha Jayasankar, Barbara Rodríguez-Spong |
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| Rok vydání: | 2004 |
| Předmět: |
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Molecular Phase transition Chemical Phenomena Chemistry Pharmaceutical Nabumetone Molecular Conformation Supramolecular chemistry Pharmaceutical Science Nanotechnology Crystal engineering Chemistry Techniques Analytical Phase Transition law.invention Excipients Molecular recognition Drug Stability Sulfapyridine law Humans Molecule Crystallization Active ingredient Crystallography Molecular Structure Chemistry Physical Chemistry Energy landscape Hydrogen Bonding General Medicine Butanones Kinetics Carbamazepine Pharmaceutical Preparations Polymorphism (materials science) Chemical physics Solvents Thermodynamics |
| Zdroj: | ChemInform. 35 |
| ISSN: | 1522-2667 0931-7597 |
| DOI: | 10.1002/chin.200437276 |
| Popis: | The diversity of solid-state forms that an active pharmaceutical ingredient (API) may attain relies on the repertoire of non-covalent interactions and molecular assemblies, the range of order, and the balance between entropy and enthalpy that defines the free energy landscape. It is recognized that crystallization is associated with molecular recognition events that lead to self-assembly, and that pharmaceutical function and thermodynamic stability can be altered with a slight change in the interacting molecules or their molecular network motifs. Our current understanding of pharmaceutical solids in terms of molecular recognition and complementarity provides new insights into the design and function of single and fully miscible, multiple-component solids with varying degrees of order, from amorphous to crystalline states, and in this way is leading the path to supramolecular pharmaceutics. This review describes pharmaceutical solids in terms of supramolecular chemistry and crystal engineering concepts, and discusses the events that control crystallization and solid phase transformations. |
| Databáze: | OpenAIRE |
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