Dysinosins B−D, Inhibitors of Factor VIIa and Thrombin from the Australian SpongeLamellodysideachlorea
| Autor: | Moana Simpson, Ronald J. Quinn, Edward G. Hyde, Malcolm Stewart Buchanan, Annette Edser, Anthony R. Carroll |
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| Rok vydání: | 2004 |
| Předmět: |
Proteases
Indoles Stereochemistry Pharmaceutical Science Peptide Factor VIIa Analytical Chemistry Serine Structure-Activity Relationship Thrombin Drug Discovery medicine Animals Structure–activity relationship Pyrroles Nuclear Magnetic Resonance Biomolecular Pharmacology chemistry.chemical_classification Molecular Structure biology Chemistry Organic Chemistry Australia Anticoagulants Biological activity Porifera Enzyme Complementary and alternative medicine Biochemistry Enzyme inhibitor biology.protein Molecular Medicine circulatory and respiratory physiology medicine.drug |
| Zdroj: | Journal of Natural Products. 67:1291-1294 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np049968p |
| Popis: | Three new marine natural products, dysinosins B-D (1-3), were isolated from the sponge Lamellodysidea chlorea and their structures determined by 1D and 2D NMR spectroscopy. These compounds are inhibitors of the blood coagulation cascade serine proteases factor VIIa and thrombin. These analogues, dysinosins B-D (1-3), allowed identification of two structural motifs within the structures that contribute to binding to the proteases, factor VIIa and thrombin. |
| Databáze: | OpenAIRE |
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