Plasma levels of acylated ghrelin in patients with insulinoma and expression of ghrelin and its receptor in insulinomas
| Autor: | Yupei Zhao, Chunmei Bai, Naishi Li, Yuan-Jia Chen, Qiang Wang, Yu-Li Song, Yu Xiao, Hai-Yan Wu, Ming Li, Shuang Yu |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
endocrine system medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Hyperproinsulinemia BMI 03 medical and health sciences 0302 clinical medicine Endocrinology Diabetes mellitus Internal medicine medicine Hyperinsulinemia Humans Insulin Obesity Receptors Ghrelin Receptor Insulinoma Proinsulin business.industry digestive oral and skin physiology medicine.disease Ghrelin Pancreatic Neoplasms 030104 developmental biology Original Article business hormones hormone substitutes and hormone antagonists Growth hormone secretagogue receptor (GHS-R) |
| Zdroj: | BASE-Bielefeld Academic Search Engine Endocrine |
| ISSN: | 1559-0100 1355-008X |
| DOI: | 10.1007/s12020-020-02233-4 |
| Popis: | Background Insulinoma is a subtype of pancreatic neuroendocrine tumors. Many patients with insulinoma are obese due to frequent food intake. Ghrelin is associated with obesity and blood levels of insulin. It is not clear if plasma levels of ghrelin in insulinoma patients correlate with hyperinsulinemia and obesity. Expression of ghrelin and its receptor has not been well demonstrated in insulinoma. Objective To study if plasma levels of ghrelin is associated with obesity and hyperinsulinemia or hyperproinsulinemia in patients with insulinoma, and to detect the expression of ghrelin and its receptor in insulinoma. Methods Plasma levels of acylated ghrelin, insulin, and proinsulin were measured in 37 patients with insulinoma and 25 controls by ELISA. Expression of ghrelin and its receptor GHS-R1A was examined in 20 insulinoma and paired pancreatic specimens by immunostaining. P ≤ 0.05 was considered significant. Results The plasma levels of acylated ghrelin in patients with insulinoma were significantly lower than that in the controls (median 15 pg/ml vs. 19 pg/ml, respectively, P = 0.016). The reduced plasma levels of acylated ghrelin in patients were significantly correlated with obesity, hyperinsulinemia, and hyperproinsulinemia (P = 0.029 and P = 0.028, respectively). Expression of ghrelin and its receptor GHS-R1A was shown in the majority of insulinoma specimens. The expression of GHS-R1A was positively correlated with ghrelin expression in insulinoma (P = 0.014). Conclusions Plasma levels of acylated ghrelin decreased in patients with insulinoma, probably due to the hyperinsulinemia and obesity in the patients. Expression of both ghrelin and its receptor is common in insulinoma. |
| Databáze: | OpenAIRE |
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