Single-dose serotonergic stimulation shows widespread effects on functional brain connectivity
| Autor: | Najmeh Khalili-Mahani, Jeroen van der Grond, Serge A.R.B. Rombouts, Joop M. A. van Gerven, Helene C. van Gorsel, Bernadet L. Klaassens, Brandon Whitcher, Bradley T. Wyman |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Serotonin Hydrocortisone Cognitive Neuroscience Serotonin reuptake inhibitor Precuneus Neuropsychological Tests Serotonergic Brain mapping Functional connectivity Young Adult Neuropharmacology Double-Blind Method Neuroimaging Sertraline medicine SSRI Humans Default mode network Brain Mapping Cross-Over Studies Brain Magnetic Resonance Imaging Prolactin Resting state networks medicine.anatomical_structure Neurology FMRI Posterior cingulate Female Psychology Neuroscience Selective Serotonin Reuptake Inhibitors medicine.drug |
| Zdroj: | NeuroImage, 122, 440-450 |
| ISSN: | 1053-8119 |
| DOI: | 10.1016/j.neuroimage.2015.08.012 |
| Popis: | The serotonergic system is widely distributed throughout the central nervous system. It is well known as a mood regulating system, although it also contributes to many other functions. With resting state functional magnetic resonance imaging (RS-fMRI) it is possible to investigate whole brain functional connectivity. We used this non-invasive neuroimaging technique to measure acute pharmacological effects of the selective serotonin reuptake inhibitor sertraline (75 mg) in 12 healthy volunteers. In this randomized, double blind, placebo-controlled, crossover study, RS-fMRI scans were repeatedly acquired during both visits (at baseline and 3, 5, 7 and 9h after administering sertraline or placebo). Within-group comparisons of voxelwise functional connectivity with ten functional networks were examined (p |
| Databáze: | OpenAIRE |
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