Effects of different dietary regimes alone or in combination with standardized Aronia melanocarpa extract supplementation on lipid and fatty acids profiles in rats
Autor: | Isidora Milosavljevic, Jovana Jeremic, Nevena Jeremic, Ivan Srejovic, Miroslav Mitrovic, Vesna Vucic, Sergey Bolevich, Aleksandra Arsic, Tamara Nikolic Turnic, Stefani Bolevich, Jovana Bradic, Milica Labudovic Borovic, Vladimir Jakovljevic, Petar S. Milić, Vladimir Zivkovic |
---|---|
Rok vydání: | 2019 |
Předmět: |
Fatty Acid Desaturases
Male 0301 basic medicine medicine.medical_specialty Fatty Acid Elongases Clinical chemistry Clinical Biochemistry Dietary pattern Systemic inflammation Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Photinia parasitic diseases medicine TBARS Animals Palmitoleic acid Rats Wistar Fatty acids Molecular Biology chemistry.chemical_classification Plant Extracts business.industry Fatty Acids Lipid profiles Cell Biology General Medicine medicine.disease Aronia melanocarpa Metabolic syndrome Diet 030104 developmental biology Endocrinology chemistry 030220 oncology & carcinogenesis Dietary Supplements lipids (amino acids peptides and proteins) medicine.symptom business Lipoprotein Polyunsaturated fatty acid |
Zdroj: | Molecular & Cellular Biochemistry |
ISSN: | 1573-4919 0300-8177 |
Popis: | This study investigated different dietary strategies, high-fat (HFd), or standard diet (Sd) alone or in combination with standardized Aronia melanocarpa extract (SAE), as a polyphenol-rich diet, and their effects on lipids and fatty acids (FA) in rats with metabolic syndrome (MetS). Wistar albino rats were randomly divided into two groups: healthy and rats with MetS, and then depending on dietary patterns on six groups: healthy rats fed with Sd, healthy rats fed with Sd and SAE, rats with MetS fed with HFd, rats with MetS fed with HFd and SAE, rats with MetS fed with Sd, and rats with MetS fed with Sd and SAE. 4 weeks later, after an overnight fast (12-14 h), blood for determination of total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), index of lipid peroxidation (measured as TBARS), and FA was collected. Increased FA and lipid concentration found in MetS rats were reduced when changing dietary habits from HFd to Sd with or without SAE consumption. Consumption of SAE slightly affects the FA profiles, mostly palmitoleic acid in healthy rats and PUFA in MetS + HFd rats. Nevertheless, in a high-fat diet, SAE supplementation significantly decreases n-6/n-3 ratio, thereby decreasing systemic inflammation. Further researches are warranted to confirm these effects in humans. |
Databáze: | OpenAIRE |
Externí odkaz: |