Effects of different dietary regimes alone or in combination with standardized Aronia melanocarpa extract supplementation on lipid and fatty acids profiles in rats

Autor: Isidora Milosavljevic, Jovana Jeremic, Nevena Jeremic, Ivan Srejovic, Miroslav Mitrovic, Vesna Vucic, Sergey Bolevich, Aleksandra Arsic, Tamara Nikolic Turnic, Stefani Bolevich, Jovana Bradic, Milica Labudovic Borovic, Vladimir Jakovljevic, Petar S. Milić, Vladimir Zivkovic
Rok vydání: 2019
Předmět:
Fatty Acid Desaturases
Male
0301 basic medicine
medicine.medical_specialty
Fatty Acid Elongases
Clinical chemistry
Clinical Biochemistry
Dietary pattern
Systemic inflammation
Lipid peroxidation
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Photinia
parasitic diseases
medicine
TBARS
Animals
Palmitoleic acid
Rats
Wistar
Fatty acids
Molecular Biology
chemistry.chemical_classification
Plant Extracts
business.industry
Fatty Acids
Lipid profiles
Cell Biology
General Medicine
medicine.disease
Aronia melanocarpa
Metabolic syndrome
Diet
030104 developmental biology
Endocrinology
chemistry
030220 oncology & carcinogenesis
Dietary Supplements
lipids (amino acids
peptides
and proteins)
medicine.symptom
business
Lipoprotein
Polyunsaturated fatty acid
Zdroj: Molecular & Cellular Biochemistry
ISSN: 1573-4919
0300-8177
Popis: This study investigated different dietary strategies, high-fat (HFd), or standard diet (Sd) alone or in combination with standardized Aronia melanocarpa extract (SAE), as a polyphenol-rich diet, and their effects on lipids and fatty acids (FA) in rats with metabolic syndrome (MetS). Wistar albino rats were randomly divided into two groups: healthy and rats with MetS, and then depending on dietary patterns on six groups: healthy rats fed with Sd, healthy rats fed with Sd and SAE, rats with MetS fed with HFd, rats with MetS fed with HFd and SAE, rats with MetS fed with Sd, and rats with MetS fed with Sd and SAE. 4 weeks later, after an overnight fast (12-14 h), blood for determination of total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), index of lipid peroxidation (measured as TBARS), and FA was collected. Increased FA and lipid concentration found in MetS rats were reduced when changing dietary habits from HFd to Sd with or without SAE consumption. Consumption of SAE slightly affects the FA profiles, mostly palmitoleic acid in healthy rats and PUFA in MetS + HFd rats. Nevertheless, in a high-fat diet, SAE supplementation significantly decreases n-6/n-3 ratio, thereby decreasing systemic inflammation. Further researches are warranted to confirm these effects in humans.
Databáze: OpenAIRE
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