Nonlinear Relationship between Birth Weight and Visceral Fat in Adolescents
| Autor: | Bernard Gutin, Norman K. Pollock, Joshua T. Nguyen, Jatinder Bhatia, Mary Ellen Fain, Brian K. Stansfield |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Birth weight Adipose tissue 030209 endocrinology & metabolism Type 2 diabetes Intra-Abdominal Fat Article Body Mass Index Cohort Studies 03 medical and health sciences 0302 clinical medicine Insulin resistance Risk Factors Internal medicine medicine Birth Weight Humans 030212 general & internal medicine Adiposity Adiponectin business.industry Leptin medicine.disease Subcutaneous Fat Abdominal Endocrinology Diabetes Mellitus Type 2 Socioeconomic Factors Cardiovascular Diseases Pediatrics Perinatology and Child Health Female Metabolic syndrome business Body mass index |
| Zdroj: | The Journal of pediatrics. 174 |
| ISSN: | 1097-6833 |
| Popis: | To determine the association of birth weight with abdominal fat distribution and markers known to increase risk for cardiovascular disease and type 2 diabetes in adolescents.In 575 adolescents aged 14-18 years (52% female, 46% black), birth weight was obtained by parental recall. Fasting blood samples were measured for glucose, insulin, lipids, adiponectin, leptin, and C-reactive protein. Subcutaneous abdominal adipose tissue and visceral adipose tissue were assessed by magnetic resonance imaging.When we compared markers of cardiometabolic risk across tertiles of birth weight, adjusting for age, sex, race, Tanner stage, physical activity, socioeconomic status, and body mass index, there were significant U-shaped trends for homeostasis model assessment of insulin resistance, leptin, and visceral adipose tissue (all Pquadratic .05). A significant linear downward trend across tertiles of birth weight was observed for triglycerides (Plinear = .03). There were no differences in fasting glucose, blood pressure, total cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, adiponectin, C-reactive protein, or subcutaneous abdominal adipose tissue across tertiles of birth weight.Our data suggest that both low and high birth weights are associated with greater visceral adiposity and biomarkers implicated in insulin resistance and inflammation in adolescents. |
| Databáze: | OpenAIRE |
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