A Novel Reduced Graphene Oxide Modified Carbon Paste Electrode for Potentiometric Determination of Trihexyphenidyl Hydrochloride in Pharmaceutical and Biological Matrices
| Autor: | Josip Radić, Bostjan Genorio, Ema Gričar, Mitja Kolar, Maša Buljac |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
elektrode iz ogljikove paste
Potentiometric titration Oxide urine samples 02 engineering and technology TP1-1185 trihexyphenidyl hydrochloride pharmaceuticals triheksifenidil hidroklorid 01 natural sciences Biochemistry reduced graphene oxide Article Analytical Chemistry law.invention potenciometrija chemistry.chemical_compound law potentiometry carbon paste electrode udc:543.554 reduciran grafen oksid Graphite Electrical and Electronic Engineering Electrodes Instrumentation Trihexyphenidyl Hydrochloride Graphene Chemical technology 010401 analytical chemistry Reproducibility of Results urinski vzorci 021001 nanoscience & nanotechnology Carbon Atomic and Molecular Physics and Optics Trihexyphenidyl 0104 chemical sciences Carbon paste electrode Solvent Pharmaceutical Preparations chemistry Electrode 0210 nano-technology farmacevtske učinkovine Nuclear chemistry |
| Zdroj: | Sensors, Vol 21, Iss 2955, p 2955 (2021) Sensors Volume 21 Issue 9 Sensors, vol. 21, no. 9, 2955, 2021. Sensors (Basel, Switzerland) |
| ISSN: | 1424-8220 |
| Popis: | A novel promising carbon paste electrode with excellent potentiometric properties was prepared for the analysis of trihexyphenidyl hydrochloride (THP), the acetylcholine receptor and an anticholinergic drug in real samples. It contains 10.2% trihexyphenidy-tetraphenylborate ionic pair as the electroactive material, with the addition of 3.9% reduced graphene oxide and 0.3% of anionic additive into the paste, which consists of 45.0% dibutylphthalate as the solvent mediator and 40.6% graphite. Under the optimized experimental conditions, the electrode showed a Nernstian slope of 58.9 ± 0.2 mV/decade with a regression coefficient of 0.9992. It exhibited high selectivity and reproducibility as well as a fast and linear dynamic response range from 4.0 × 10−7 to 1.0 × 10−2 M. The electrode remained usable for up to 19 days. Analytical applications showed excellent recoveries ranging from 96.8 to 101.7%, LOD was 2.5 × 10−7 M. The electrode was successfully used for THP analysis of pharmaceutical and biological samples. |
| Databáze: | OpenAIRE |
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