| Autor: |
Holger Stephan, Ralf Kirchner, Anika Röhrich, Jörg Steinbach, Steffi Noll, Jürgen Seidel |
| Jazyk: |
angličtina |
| Rok vydání: |
2007 |
| Předmět: |
|
| Zdroj: |
Tetrahedron Letters 48(2007), 8834-8838 |
| Popis: |
Two novel glycocluster ligands with cyclam core bearing thiourea-linked d -glucose and 2-acetamido-2-deoxy- d -glucose at the periphery have been synthesized. The interaction with concanavalin A has been studied by isothermal titration microcalorimetry for characterizing protein-ligand interactions. The sugar-containing multivalent ligands showed higher association affinity compared to the sugar monomers, which is attributed to an entropy driven glycoside clustering effect. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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