Lipoprotein Response to Diets High in Soy or Animal Protein With and Without Isoflavones in Moderately Hypercholesterolemic Subjects
| Autor: | Ernst J. Schaefer, Lynne M. Ausman, Alice H. Lichtenstein, Helen Rasmussen, Susan M Jalbert, Herman Adlercreutz, Barry R. Goldin |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Lipoproteins Saturated fat Hypercholesterolemia Blood lipids Biology chemistry.chemical_compound Internal medicine medicine Animals Humans Soy protein Animal fat Triglyceride Cholesterol Fasting Middle Aged Isoflavones Lipids Postmenopause Apolipoproteins Endocrinology chemistry Soybean Proteins Female lipids (amino acids peptides and proteins) Dietary Proteins Cardiology and Cardiovascular Medicine Lipoprotein |
| Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology. 22:1852-1858 |
| ISSN: | 1524-4636 1079-5642 |
| DOI: | 10.1161/01.atv.0000033513.18431.a1 |
| Popis: | Objective— The objective of this study was to assess the independent effect of soy relative to common sources of animal protein and soy-derived isoflavones on blood lipids. Methods and Results— Forty-two subjects with LDL cholesterol levels ≥3.36 mmol/L were fed each of four diets in randomized order for 6 weeks per phase. Diets contained a minimum of 25 g animal protein or isolated soy protein/4.2 MJ, with each containing trace amounts or 50 mg of isoflavones/4.2 MJ. Soy protein had a modest effect on total, LDL and HDL cholesterol, and triglyceride concentrations (−2%, P =0.017; −2%, P =0.042; +3%; P =0.034, −11%, P P =0.001; −5%, P =0.003; −15%, P Conclusions— Although potentially helpful when used to displace products containing animal fat from the diet, the regular intake of relatively high levels of soy protein (>50 g/day) had only a modest effect on blood cholesterol levels and only in subjects with elevated LDL cholesterol levels (≥4.14 mmol/L). Soy-derived isoflavones had no significant effect. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|