Efficacy of Citrus maxima fruit segment supplemented paranthas in STZ induced diabetic rats
| Autor: | Shinde Vijay Sukhdeo, Sudha Madhugiri Lakshminarayan, Reshmi Somanathan Karthiga, Shashirekha Mysuru Nanjarajurs |
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| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
Male Citrus Astringent 030309 nutrition & dietetics medicine.medical_treatment Renal function Diabetes Mellitus Experimental 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology Diabetes mellitus medicine Animals Hypoglycemic Agents Insulin Food science Rats Wistar Naringin 0303 health sciences business.industry Plant Extracts 04 agricultural and veterinary sciences medicine.disease 040401 food science Bioavailability Metformin Rats chemistry Dietary Supplements Flavanones medicine.symptom business Weight gain Food Science medicine.drug |
| Zdroj: | Journal of food scienceREFERENCES. 86(5) |
| ISSN: | 1750-3841 |
| Popis: | The study was conducted to investigate the efficacy of Citrus maxima (Pomelo) fruit segments fortified paranthas compared to pomelo juice and naringin in streptozotocin-induced diabetic rats. The animals were divided into nine groups, Groups 1 to 3: negative control; Group 4: diabetic control; Groups 5 through 8: treatments with pomelo juice, naringin, plain paranthas, and pomelo supplemented paranthas; and Group 9 was positive control metformin. The groups were monitored for weight, oral glucose tolerance, insulin tolerance, bioavailability, biochemical parameters, and histopathological studies. Based on the result the group treated with paranthas fortified with pomelo fruit segment (Group 8) showed 19% of overall weight gain, approximately 50% reduction in plasma glucose level and improved serum protein (5.70 g/dl) and serum insulin (8.54 ng/ml) level as compared against diabetic control. The treatments had effectively lowered the level of liver enzyme and lipids (except HDL) in the serum along with the improved renal function. The group treated with pomelo juice and pomelo supplemented paranthas exhibited marked tolerance to the glucose and insulin similar to the positive control. Therefore, the antidiabetic activity was found to be more pronounced in the order of pomelo juice > fortified paranthas > naringin. Since pomelo juice is bitter and astringent in nature, the fruit can be better utilized in the form of fortified paranthas, which exerts antidiabetic effect similar to the positive control metformin. Hence, paranthas supplemented with pomelo fruit segments (bioactives-rich) aids in the reducing the risk of diabetes and can be recommended to gain nutritional benefits for normal and diabetic populations. |
| Databáze: | OpenAIRE |
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