The need and Potential of Biosensors to Detect Dioxins and Dioxin-Like Polychlorinated Biphenyls along the Milk, Eggs and Meat Food Chain
| Autor: | Bastiaan G. Meerburg, Imke J.M. de Boer, Willem Haasnoot, Aize Kijlstra, Jeerasak Chobtang, Ron L.A.P. Hoogenboom |
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| Přispěvatelé: | Oogheelkunde, RS: MHeNs School for Mental Health and Neuroscience |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Meat
RIKILT - R&C Diergeneesmiddelen polychlorinated biphenyls Eggs free-range eggs Biosensing Techniques Review biosensor lcsh:Chemical technology Biochemistry Animal Production Systems Analytical Chemistry Matrix (chemical analysis) microbial biosensors Food chain dibenzo-p-dioxins dioxins calux-bioassay CALUX Animals lcsh:TP1-1185 solid-phase extraction Electrical and Electronic Engineering home-produced eggs Luciferase Gene Instrumentation Trophic level Dierlijke Productiesystemen Chemistry dr-calux(r) bioassay Research aryl-hydrocarbon receptor chemical contamination Contamination toxic equivalency factors Atomic and Molecular Physics and Optics Milk food chain Human exposure Environmental chemistry WIAS Biosensor Rikilt B&T Toxicologie en Effectanalyse Wageningen Livestock Research Onderzoek |
| Zdroj: | Sensors, 11(12), 11692-11716 Sensors, Vol 11, Iss 12, Pp 11692-11716 (2011) Sensors (Basel, Switzerland) Sensors 11 (2011) 12 Sensors, 11(12), 11692-11716. MDPI AG |
| ISSN: | 1424-8220 |
| Popis: | Dioxins and dioxin-like polychlorinated biphenyls (DL-PCBs) are hazardous toxic, ubiquitous and persistent chemical compounds, which can enter the food chain and accumulate up to higher trophic levels. Their determination requires sophisticated methods, expensive facilities and instruments, well-trained personnel and expensive chemical reagents. Ideally, real-time monitoring using rapid detection methods should be applied to detect possible contamination along the food chain in order to prevent human exposure. Sensor technology may be promising in this respect. This review gives the state of the art for detecting possible contamination with dioxins and DL-PCBs along the food chain of animal-source foods. The main detection methods applied (i.e., high resolution gas-chromatography combined with high resolution mass-spectrometry (HRGC/HRMS) and the chemical activated luciferase gene expression method (CALUX bioassay)), each have their limitations. Biosensors for detecting dioxins and related compounds, although still under development, show potential to overcome these limitations. Immunosensors and biomimetic-based biosensors potentially offer increased selectivity and sensitivity for dioxin and DL-PCB detection, while whole cell-based biosensors present interpretable biological results. The main shortcoming of current biosensors, however, is their detection level: this may be insufficient as limits for dioxins and DL-PCBs for food and feedstuffs are in pg per gram level. In addition, these contaminants are normally present in fat, a difficult matrix for biosensor detection. Therefore, simple and efficient extraction and clean-up procedures are required which may enable biosensors to detect dioxins and DL-PCBs contamination along the food chain. |
| Databáze: | OpenAIRE |
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