A database for inventory of proteoform profiles: '2DE‐pattern'
| Autor: | Stanislav N. Naryzhny, Natalia V. Belyakova, Elena Zorina, Olga A. Kleyst, Nikolay Klopov, Olga K. Legina, Victor G. Zgoda, Natalia L. Ronzhina |
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| Rok vydání: | 2020 |
| Předmět: |
Proteomics
Proteome Database Computer science 010401 analytical chemistry Clinical Biochemistry Protein species 02 engineering and technology 021001 nanoscience & nanotechnology computer.software_genre 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry Tandem Mass Spectrometry Human proteome project Humans Protein Isoforms Electrophoresis Gel Two-Dimensional Databases Protein 0210 nano-technology computer Chromatography Liquid |
| Zdroj: | ELECTROPHORESIS. 41:1118-1124 |
| ISSN: | 1522-2683 0173-0835 |
| DOI: | 10.1002/elps.201900468 |
| Popis: | The human proteome is composed of a diverse and heterogeneous range of gene products/proteoforms/protein species. Because of the growing amount of information about proteoforms generated by different methods, we need a convenient approach to make an inventory of the data. Here, we present a database of proteoforms that is based on information obtained by separation of proteoforms using 2DE followed by shotgun ESI-LC-MS/MS. The database's principles and structure are described. The database is called "2DE-pattern" as it contains multiple isoform-centric patterns of proteoforms separated according to 2DE principles. The database can be freely used at http://2de-pattern.pnpi.nrcki.ru. |
| Databáze: | OpenAIRE |
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