Measuring prevalence and incidence of chronic conditions in claims and electronic health record databases
| Autor: | William Murk, Amanda R. Patrick, Jeremy A. Rassen, Sebastian Schneeweiss, Dorothee B. Bartels |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
pharmacoepidemiology Epidemiology Cross-sectional study epidemiologic methods prevalence sentinel surveillance cross-sectional studies Disease computer.software_genre secondary databases 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Electronic health record Health care Medicine Clinical Epidemiology 030212 general & internal medicine Original Research epidemiological monitoring prevalence studies Database business.industry Incidence (epidemiology) Pharmacoepidemiology incidence Epidemiological Monitoring business computer |
| Zdroj: | Clinical Epidemiology |
| ISSN: | 1179-1349 |
| DOI: | 10.2147/clep.s181242 |
| Popis: | Jeremy A Rassen,1 Dorothee B Bartels,2 Sebastian Schneeweiss,1,3,4 Amanda R Patrick,1 William Murk1,5 1Aetion, Inc, New York, NY, USA; 2BI X GmbH, Ingelheim, Germany; 3Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital, Boston, MA, USA; 4Harvard Medical School, Boston, MA, USA; 5Jacobs School of Medicine, University at Buffalo, Buffalo, NY, USA Background: Health care databases are natural sources for estimating prevalence and incidence of chronic conditions, but substantial variation in estimates limits their interpretability and utility. We evaluated the effects of design choices when estimating prevalence and incidence in claims and electronic health record databases. Methods: Prevalence and incidence for five chronic diseases at increasing levels of expected frequencies, from cystic fibrosis to COPD, were estimated in the Clinical Practice Research Datalink (CPRD) and MarketScan databases from 2011 to 2014. Estimates were compared using different definitions of lookback time and contributed person-time. Results: Variation in lookback time substantially affected estimates. In 2014, for CPRD, use of an all-time vs a 1-year lookback window resulted in 4.3–8.3 times higher prevalence (depending on disease), reducing incidence by 1.9–3.3 times. All-time lookback resulted in strong temporal trends. COPD prevalence between 2011 and 2014 in MarketScan increased by 25% with an all-time lookback but stayed relatively constant with a 1-year lookback. Varying observability did not substantially affect estimates. Conclusion: This framework draws attention to the underrecognized potential for widely varying incidence and prevalence estimates, with implications for care planning and drug development. Though prevalence and incidence are seemingly straightforward concepts, careful consideration of methodology is required to obtain meaningful estimates from health care databases. Keywords: epidemiology, epidemiologic methods, epidemiological monitoring, sentinel surveillance, pharmacoepidemiology, cross-sectional studies, secondary databases, prevalence, prevalence studies, incidence |
| Databáze: | OpenAIRE |
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