| Autor: |
Ndiaye, Yaye Die, Wong, Wesley, Thwing, Julie, Schaffner, Stephen S, Tine, Abdoulaye, Diallo, Mamadou Alpha, Deme, Awa, Sy, Mouhammad, Bei, Amy K, Thiaw, Alphonse B, Daniels, Rachel, Ndiaye, Tolla, Gaye, Amy, Ndiaye, Ibrahima Mbaye, Toure, Mariama, Gadiaga, Nogaye, Sene, Aita, Sow, Djiby, Garba, Mamane N., Yade, Mamadou Samba, Dieye, Baba, Diongue, Khadim, Zoumarou, Daba, Ndiaye, Aliou, Gomis, Jules, Fall, Fatou Ba, Ndiop, Medoune, Diallo, Ibrahima, Sene, Doudou, Macinnis, Bronwyn, Seck, Mame Cheikh, Ndiaye, Mouhamadou, Badiane, Aida S., Hartl, Daniel L., Volkman, Sarah K., Wirth, Dyann F., Ndiaye, Daouda |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
medRxiv |
| Popis: |
Drug resistance inPlasmodium falciparumis a major threat to malaria control efforts. We analyzed data from two decades (2000-2020) of continuous molecular surveillance ofP. falciparumparasite strains in Senegal to determine how historical changes in drug administration policy may have affected parasite evolution. We profiled several known drug resistance markers and their surrounding haplotypes using a combination of single nucleotide polymorphism (SNP) molecular surveillance and whole-genome sequence (WGS) based population genomics. We observed rapid changes in drug resistance markers associated with the withdrawal of chloroquine and introduction of sulfadoxine-pyrimethamine in 2003. We also observed a rapid increase inPfcrtK76T and decline inPfdhpsA437G starting in 2014, which we hypothesize may reflect changes in resistance or fitness caused by seasonal malaria chemoprevention (SMC). Parasite populations evolve rapidly in response to drug use, and SMC preventive efficacy should be closely monitored. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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