Infectious complications in HIV-infected kidney transplant recipients

Autor: Benoit Barrou, M Turinici, G Mircescu, Jérôme Tourret, R O Calin, N Arzouk, M.A. Valantin, O. Ailioaie
Rok vydání: 2017
Předmět:
Adult
Graft Rejection
Male
medicine.medical_specialty
medicine.medical_treatment
AIDS-Related Opportunistic Infections
Population
030232 urology & nephrology
HIV Infections
Dermatology
030230 surgery
03 medical and health sciences
Postoperative Complications
0302 clinical medicine
Antiretroviral Therapy
Highly Active
Internal medicine
medicine
Humans
Pharmacology (medical)
Renal Insufficiency
education
Dialysis
Kidney transplantation
Retrospective Studies
Immunosuppression Therapy
education.field_of_study
business.industry
Incidence
Incidence (epidemiology)
Graft Survival
Public Health
Environmental and Occupational Health
Immunosuppression
Middle Aged
medicine.disease
Kidney Transplantation
Transplantation
Treatment Outcome
Infectious Diseases
Case-Control Studies
Relative risk
Female
business
Immunosuppressive Agents
Zdroj: International Journal of STD & AIDS. 29:341-349
ISSN: 1758-1052
0956-4624
DOI: 10.1177/0956462417726213
Popis: Renal transplantation is now a viable alternative for dialysis in HIV-infected patients who achieve good immunovirological control with current antiretroviral therapy regimens available. However, there are few studies that analyze the incidence of post-transplant infections in this population. In this study, a retrospective analysis of data files of 24 HIV-infected kidney transplant (KT) recipients was undertaken, matched to 21 non-infected controls. All patients received induction with anti-interleukin-2 antibodies and were followed in the Pitié-Salpêtrière Hospital in Paris, France. The rate of incidence of post-transplant infections was 23.58 and 26.98/100 patient-years, in HIV-infected and HIV-negative groups (relative risk [RR]: 0.90; 95% confidence interval [CI]: 0.58–1.39; p = 0.63). In HIV-infected KT recipients, bacterial infections were the most frequent (67.7%), followed by viral (14.7%) and fungal and parasitic infections (8.8%). Similar trends were seen in the control group. Incidence of opportunistic infections was similar in HIV-infected KT recipients and controls (38.2 vs. 26.5%; p = 0.44). There were three post-transplant HIV reactivations in two patients, secondary to poor adherence to medication. HIV status did not influence survival, but infections increased the risk of unfavorable outcome. Incidence of post-transplant infections was similar in HIV-infected KT recipients and controls. Infections, but not HIV status, had adverse effects on patient and graft survival.
Databáze: OpenAIRE
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