Impact of lockdown COVID-19 on metabolic control in type 2 diabetes mellitus and healthy people

Autor: Tijen Yesim, Selvihan Beysel, Savas Karatas
Rok vydání: 2021
Předmět:
Blood Glucose
Male
Turkey
BMI
body mass index
COVİD-19 lockdown
Endocrinology
Diabetes and Metabolism
Metabolic disorders
Comorbidity
Type 2 diabetes
Body Mass Index
0302 clinical medicine
WC
waist circumference
Prospective Studies
030212 general & internal medicine
Prospective cohort study
Original Research
Nutrition and Dietetics
TG
triglyceride
Diabetes
Middle Aged
COVID-19
Coronavirus Disease 2019
Quarantine
Female
medicine.symptom
Family Practice
medicine.medical_specialty
HbA1c
haemoglobin A1c
030209 endocrinology & metabolism
HDL-C
high-density lipoprotein-cholesterol
03 medical and health sciences
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Humans
LDL-C
low-density lipoprotein-cholesterol
FPG
fasting plasma glucose
Pandemics
Weight gain
Retrospective Studies
SARS-CoV-2
business.industry
COVID-19
Type 2 Diabetes Mellitus
medicine.disease
Endocrinology
Diabetes Mellitus
Type 2
Metabolic control analysis
Communicable Disease Control
Blood sugar regulation
business
Body mass index
Zdroj: Primary Care Diabetes
ISSN: 1751-9918
DOI: 10.1016/j.pcd.2021.01.003
Popis: Highlights • Pandemic lockdowns have caused deterioration in diet and exercise, according to recent studies. • Diabetes patients and non-diabetes patients gained weight in the pandemic period. • HbA1c, blood glucose, and lipid levels were increased in diabetes patients. • No significant change in blood glucose levels of non-diabetes subjects was observed. • There was a nonsignificant decrease in LDL and TG levels of non-diabetes subjects.
Aims The impact of prolonged COVID-19 lockdown on metabolic control in type 2 diabetes patients and healthy individuals has not exactly been known. We aimed to evaluate the change in body weight and metabolic control in type 2 diabetic and non-diabetic healthy subjects during the prolonged lockdown period. Methods Diabetic (n = 85), and age-and sex-matched non-diabetic subjects (n = 55) were included in this prospective study. Body mass index and metabolic parameters were compared between before and 6th months of lockdown. Changes in values were evaluated using the difference before and after lockdown. Results Age (54.81 ± 10.53 vs. 52.61 ± 4.88 years), gender (female, 68.2% vs. 56.4%) and, BMI (33.44 ± 6.48 vs. 31.63 ± 3.57 kg/m2) were similar between groups (p > 0.05). Before and after lockdown, BMI increased both in non-diabetic (0.54 ± 0.95 kg) and diabetic groups (1.91 ± 5.48 kg) (p > 0.05). Increase in HbA1c was more in diabetic than in non-diabetic groups (0.71 ± 1.35 vs. 0.02 ± 0.19%, p = 0.002). Glucose, LDL-C, and TG increased in diabetic (39.69 ± 74.69, 7.60 ± 34.33, and 58.21 ± 133.54 mg/dl, p < 0.05) whereas non significantly decreased in non-diabetic group (−0.51 ± 4.40, −3.52 ± 14.53, and −6.47 ± 41.77 mg/dl, respectively. After adjusting BMI, increase in blood glucose (p = 0.021), HbA1c (p = 0.018), and TG (p = 0.041) levels were more in diabetic than non-diabetic group. Duration of diabetes was an independent predictor of the change in HbA1c (OR: 1.2, 95% CI = 1.1–1.8, p = 0.032). Conclusions Body weight gain was observed in type 2 diabetic patients and healthy subjects. This is the first study to show that prolonged lockdown COVID-19 pandemic worsened glucose regulation and increased TG level in diabetes mellitus independent of weight gain.
Databáze: OpenAIRE
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