IgV H mutations in blastoid mantle cell lymphoma characterize a subgroup with a tendency to more favourable clinical outcome
| Autor: | Sergio Cogliatti, Dieter R. Zimmermann, Tim C. Diss, Samuel Henz, Francesco Bertoni, Michele Ghielmini, Ulrico Schmid |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Genotype Somatic cell Lymphoma Mantle-Cell Blastoid Pathology and Forensic Medicine Immunophenotyping hemic and lymphatic diseases medicine Humans Mutation frequency Survival analysis Aged Aged 80 and over biology Genes Immunoglobulin Sequence Analysis DNA Middle Aged biology.organism_classification medicine.disease Prognosis Survival Analysis Lymphoma Mutation Immunoglobulin heavy chain Mantle cell lymphoma Female Diffuse large B-cell lymphoma |
| Zdroj: | The Journal of pathology. 206(3) |
| ISSN: | 0022-3417 |
| Popis: | Mantle cell lymphoma (MCL) is associated with a very unfavourable clinical course. This is particularly true for mantle cell lymphoma of the blastoid subtype (MCL-b). In order to define prognostic factors, we analysed the impact of immunoglobulin heavy chain variable (IgV H) gene somatic hypermutations on clinical outcome in a series of 21 cases of morphologically, phenotypically, and genotypically well-characterized MCL-b. Testing and estimation were performed using log-rank statistics and displayed on Kaplan-Meier graphs. Thirteen of 21 cases of MCL-b revealed a homology rate of > or = 99% compared to IgV H germ-line sequences in the databases and were scored as non-mutated. Eight of 21 cases (38%) of MCL-b were mutated. In MCL-b the mutation frequency was usually low and the mutation pattern was only rarely antigen-selected, in contrast to a control group of 11 cases with morphologically almost identical, but phenotypically and genotypically clearly distinguishable, diffuse large B cell lymphoma, derived, most likely, from germinal centre B cells. In our series of 21 MCL-b, positive IgV H mutational status, irrespective of varying homology thresholds, had no statistically significant prognostic impact on event-free or overall survival. However, mutated MCL-b tended to present more frequently at an earlier stage and without bone marrow involvement and to show lower rates of relapse and death, resulting in a more favourable clinical outcome. |
| Databáze: | OpenAIRE |
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