Pigeon-serum-induced hypersensitivity pneumonitis in the dog
| Autor: | Jordan N. Fink, Viswanath P. Kurup, Hongyung Choi, Robert L. Coon, Kari Reijula, Philip S. Clifford, B. Bota |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
Allergy Immunology Inflammation Antibodies chemistry.chemical_compound Dogs Immunopathology medicine Animals Immunology and Allergy Columbidae Lung Skin Tests biology business.industry Respiratory disease medicine.disease Blood chemistry biology.protein lipids (amino acids peptides and proteins) medicine.symptom Antibody Headaches business Bronchoalveolar Lavage Fluid Histamine Hypersensitivity pneumonitis Alveolitis Extrinsic Allergic |
| Zdroj: | Allergy. 50:78-84 |
| ISSN: | 1398-9995 0105-4538 |
| Popis: | Pigeon serum (PS) is one of the most common causes of hypersensitivity pneumonitis (HP). PS-induced HP was examined in a dog model. The dogs (n = 6) were immunized by i.m. injections of PS, followed by insufflation with aerosolized PS, while all control dogs (n = 3) received saline only. All animals insufflated with PS developed tachypnea 2-4 h after PS inhalation. After PS insufflation, a significant decrease in arterial oxygen tension (PaO2) was detected in sensitized dogs. No change in PaO2 was detected in sensitized dogs after saline or in the controls after PS insufflation. In intradermal skin tests with PS antigen, a positive skin reaction was found in 3/6 dogs in 30 min, and in 5/6 dogs in 6 and 48 h after the PS injections. Sensitized dogs showed a significant increase in PS-specific IgG in serum and lavage fluid (LF). In LF of sensitized dogs, an increase in the percentage of lymphocytes, eosinophils, and neutrophils was detected. Sensitized dogs developed chronic interstitial inflammation with lymphocytes, macrophages, plasma cells, and eosinophils in lungs. Granulomas with lymphocytes, histiocytes, and giant cells were detected in both the interstitium and the bronchiolar wall in the lungs of sensitized dogs. PaO2 was lowest in dogs showing the most severe interstitial inflammation in the lungs. The results indicate that dogs can be successfully used in immunologic and physiologic studies of PS-induced HP. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text