Synthesis and antibacterial activity of a series novel 5,7-diisoprenyloxyflavone derivatives
| Autor: | Bing-Yu Liu, Zhi-Yang Fu, Ya-Nan Xia, Qing-Hao Jin, Hai-Ying Jiang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Flavonoids
biology Chemistry Antimicrobial medicine.disease_cause biology.organism_classification 030226 pharmacology & pharmacy 01 natural sciences 0104 chemical sciences Microbiology Isoprenyloxyflavones RS1-441 010404 medicinal & biomolecular chemistry 03 medical and health sciences Synthesis 0302 clinical medicine Pharmacy and materia medica Staphylococcus aureus medicine Antibacterial activity Bacteria |
| Zdroj: | Brazilian Journal of Pharmaceutical Sciences, Vol 56 (2020) Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e17721 Brazilian Journal of Pharmaceutical Sciences; v. 56 (2020); e17721 Brazilian Journal of Pharmaceutical Sciences Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 2175-9790 1984-8250 |
| Popis: | In the present study, a series of novel 5,7-diisoprenyloxyflavone derivatives were designed, synthesized, and evaluated for their antibacterial activity. Most of these compounds displayed significant antibacterial effects against Gram-positive bacteria, especially against strains of multidrug-resistant clinical isolates. Compounds 4c, 4g, 4i, 4j, 4k, 4l, 4n, 4q and 4t showed high levels of antimicrobial activity against Staphylococcus aureus RN4220 with minimum inhibitory concentrations of 4.0-20 μM. Compound 4k showed the most potent activity among these compounds against all multidrug-resistant clinical isolates tested. Unfortunately, none of the compounds were active against Gram-negative bacteria at the doses of 24-164 μM. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|