Tissue Metallothionein Concentrations in Mice and Humans with Hyperglycemia
| Autor: | Ming-Der Chen, Yuh-Min Song |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Antioxidant endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Mice Obese Adipose tissue Mice Transgenic Biochemistry Antioxidants Diabetes Mellitus Experimental Diabetes Complications Inorganic Chemistry Mice Diabetes mellitus Internal medicine Animals Humans Medicine Metallothionein Normal control business.industry Biochemistry (medical) nutritional and metabolic diseases General Medicine medicine.disease Streptozotocin Mice Inbred C57BL Zinc homeostasis Endocrinology Adipose Tissue Hyperglycemia Female business medicine.drug |
| Zdroj: | Biological Trace Element Research. 127:251-256 |
| ISSN: | 1559-0720 0163-4984 |
| DOI: | 10.1007/s12011-008-8247-z |
| Popis: | Besides participating in tissue zinc homeostasis and protecting against heavy metal toxicities, metallothionein (MT) is known as an antioxidant. Increased MT activity can ameliorate diabetic hyperglycemia, and subjects with less MT synthesis are more prone to diabetic complications. However, whether tissue MT status is varied in the subjects with diabetes mellitus remains unclear. This study was undertaken to measure tissue MT levels in laboratory mice (serum, liver, and epididymal adipose tissue) and humans (serum) with hyperglycemia. Tissue MT levels were measured by enzyme-linked immunosorbent assay. The results showed that MT status in serum and adipose tissue did not markedly differ between the subjects with and without hyperglycemia. In addition, streptozotocin- and high-fat-diet-induced hyperglycemic mice had higher while ob/ob mice had lower liver MT levels than that of normal control mice. Furthermore, serum MT levels tended to correlate with glycemia values in mice. The results of this study indicate that serum MT value does not differ in subjects with hyperglycemia and cannot be used as an index to evaluate the susceptibility or progress of diabetes mellitus. |
| Databáze: | OpenAIRE |
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