In vitro production of parathyroid hormone-related protein by cholesteatoma and normal skin
| Autor: | A. Blight, David Proops, I. M. Cheshire, W. A. Ratcliffe |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Keratinocytes
Pathology medicine.medical_specialty Inflammation Epithelium Bone resorption Mice Internal medicine otorhinolaryngologic diseases medicine Animals Humans Child Cells Cultured Skin Scalp Cholesteatoma Middle Ear Parathyroid hormone-related protein business.industry Parathyroid Hormone-Related Protein Cholesteatoma 3T3 Cells medicine.disease medicine.anatomical_structure Endocrinology Otorhinolaryngology Parathyroid Hormone Cell culture Case-Control Studies Culture Media Conditioned Protein Biosynthesis Middle ear Cytokines Female medicine.symptom business Cell Division |
| Zdroj: | Clinical Otolaryngology. 20:448-452 |
| ISSN: | 1749-4486 1749-4478 |
| DOI: | 10.1111/j.1365-2273.1995.tb00080.x |
| Popis: | Severe inflammation and infection of the middle ear occasionally results in clinical evidence of bone resorption but with the addition of the cholesteatoma epithelium it becomes inevitable. This study examined production by the cholesteatoma epithelium of a bone resorbing factor, namely parathyroid hormone-related protein (PTH-rP), which would not be expected in inflammatory states alone. PTH-rP was detected in the conditioned medium of primary and secondary cell cultures derived from 12 cholesteatoma biopsies. The levels of PTH-rP were significantly greater than in control cultures of cells derived from normal scalp tissue. Production by the cholesteatoma epithelium may explain the increased incidence of bone resorption in this disease, particularly in cases where inflammation is minimal. |
| Databáze: | OpenAIRE |
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