Screening of NogoA/NTR-related differential genes in rat sciatic nerve injury signal pathway
| Autor: | Shengjun Yu, Zhiwu Zhang, Mingchun Luan, Junjie Jiang, Fei Gao, Zhenjie Ma, Yuanchen Yu |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
MAPK/ERK pathway Nogo Proteins Apoptosis Receptors Nerve Growth Factor 030105 genetics & heredity Receptor Nerve Growth Factor Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Peripheral Nerve Injuries Neurotrophic factors medicine Animals Receptor trkB Pharmacology biology General Medicine Sciatic nerve injury medicine.disease Sciatic Nerve Nerve Regeneration Rats Cell biology 030220 oncology & carcinogenesis LDL receptor biology.protein Neuralgia Molecular Medicine Schwann Cells Sciatic Neuropathy Transcriptome Interleukin 1 receptor type I Signal Transduction Neurotrophin |
| Zdroj: | Personalized Medicine. 16:93-105 |
| ISSN: | 1744-828X 1741-0541 |
| DOI: | 10.2217/pme-2018-0088 |
| Popis: | Aim: To screen the differential genes in NogoA/NTR-related pathways that associate with sciatic nerve injury. Results: There was no difference in the expression of NogoA, NTR and Ntrk2. Differential genes existed in 11 differential pathways that include NogoA, NTR and Ntrk2. Pathways closely related to sciatic nerve injury are MAPK, endophagocytosis, apoptosis, neurotrophin signaling and inflammatory mediators. NTRK1, FASLG, LDLR ADRB1 and HTR2A in model rats were downregulated compared with control rats, IL1R1, CSF1R, BCL2L1 and HRH1 in model rats were upregulated compared with control rats. Conclusion: MAPK, endophagocytic, apoptotic, neurotrophic factor and inflammatory mediators of ductal mediators may be involved in the sciatic nerve injury in rats. The differentially expressed genes in these pathways may play important roles in sciatic nerve injury. |
| Databáze: | OpenAIRE |
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