Predicting Early Intrahepatic Recurrence After Curative Resection of Colorectal Liver Metastases with Molecular Markers
| Autor: | Tetsuro Yamamoto, Daniel Jaeck, Pietro Addeo, Philippe Bachellier, Marie-Pierre Chenard, Masato Narita, Elie Oussoultzoglou, Pascal Fuchshuber |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Survivin medicine.medical_treatment Gastroenterology Inhibitor of Apoptosis Proteins Metastasis Antigens CD Predictive Value of Tests Internal medicine Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor medicine Hepatectomy Humans AC133 Antigen Glycoproteins Retrospective Studies Chemotherapy business.industry Liver Neoplasms Case-control study Retrospective cohort study Odds ratio Middle Aged medicine.disease Primary tumor Proto-Oncogene Proteins c-bcl-2 ROC Curve Chemotherapy Adjuvant Area Under Curve Case-Control Studies Predictive value of tests Catheter Ablation Female Surgery Neoplasm Recurrence Local Colorectal Neoplasms Peptides business |
| Zdroj: | World Journal of Surgery. 39:1167-1176 |
| ISSN: | 1432-2323 0364-2313 |
| DOI: | 10.1007/s00268-014-2916-1 |
| Popis: | The aim of this case–control study was to identify clinicopathological factors and test three relevant biomarkers for their ability to predict early intrahepatic recurrence after curative liver resection for colorectal liver metastases (CLM). Of the 184 patients with CLM undergoing hepatectomy between January 2007 and December 2009, thirty patients had intrahepatic disease recurrence within 6 months. The control group was randomly selected from a cohort of patients between April 1997 and December 2005 who have survived without disease recurrence after CLM resection for over 5 years. Both groups were matched for size of metastasis greater than 5.0 cm, the presence of multiple metastases, and synchronous versus metachronous CLM. The final study population consisted of 60 patients with CLM undergoing R0 hepatectomy, 30 of whom had early intrahepatic-only recurrences (study group) and 30 patients without recurrence for more than 5 years (control group). Both groups were analyzed and compared for the presence of clinical factors and expression levels of CD133, survivin, and Bcl-2 within tumor tissue. Characteristics of patients were similar between the two groups except primary tumor location and administration of postoperative chemotherapy. Expression level of CD133 and survivin were significantly increased in tumors of patients with recurrence compared to patients without recurrence. On multivariate analysis high tumor expression levels of CD133 (odds ratio [OR] 14.7, confidence interval [CI] 1.8–121.3, p = 0.012) and survivin (OR 9.5, CI 2.1–44.3, p = 0.004) and postoperative chemotherapy (OR 4.8, CI 1.01–22.9, p = 0.049) were independent factors associated with early intrahepatic recurrence. Tumor expression levels of CD133 and survivin may be a useful predictor of early intrahepatic recurrence after hepatectomy for CLM. Administration of postoperative chemotherapy may prevent early intrahepatic recurrence. |
| Databáze: | OpenAIRE |
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