Multiple-Dose Pharmacokinetics of Moxisylyte after Oral Administration to Healthy Volunteers
| Autor: | Marc Galtier, Jacqueline Mosser, B. Sarrazin, F. Bressolle, Navratil H, Pierre Costa, Elisabeth Jarroux |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Drug Moxisylyte media_common.quotation_subject Administration Oral Pharmaceutical Science Blood Pressure Urine Pharmacology Multiple dose High-performance liquid chromatography Pharmacokinetics Heart Rate Oral administration medicine Humans Volunteer Biotransformation Chromatography High Pressure Liquid media_common Chemistry Spectrometry Fluorescence Female Spectrophotometry Ultraviolet Half-Life medicine.drug |
| Zdroj: | Journal of Pharmaceutical Sciences. 82:968-971 |
| ISSN: | 0022-3549 |
| DOI: | 10.1002/jps.2600820920 |
| Popis: | The pharmacokinetics of moxisylyte in plasma and urine was investigated after oral administration. Twelve subjects were treated orally, twice daily with 240 mg of the drug for 6 days; on day 7, the subjects received a last dose of 240 mg of moxisylyte. Moxisylyte was assayed in plasma and urine by a specific HPLC method with fluorimetric detection. Moxisylyte was absorbed rapidly and changed to its metabolites immediately after drug administration; unchanged moxisylyte was not found in plasma. Two metabolites were found in plasma and urine: conjugated desacetylmoxisylyte (DAM) and the conjugate of desmeth- ylated DAM (MDAM). The pharmacokinetic parameters determined after the first oral administration were not modified on multiple dosing. The apparent elimination half-lives of conjugated DAM and MDAM were 2.3 and 3.5 h, respectively. Elimination of these two metabolites in urine averaged 50 and 10%, respectively. |
| Databáze: | OpenAIRE |
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