Publisher Correction: Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers
| Autor: | Kathleen M. Fisch, Srinivasan Yegnasubramanian, Minya Pu, John Pang, Kate Medetgul-Ernar, Trey Ideker, Tatsuya Yamasoba, Alexander V. Favorov, Guorong Xu, Nam Bui, Sunny Haft, Yuki Saito, Akihiro Sakai, Elana J. Fertig, Adam Mark, Takahito Fukusumi, Pablo Tamayo, Chao Liu, Shuling Ren, Theresa Guo, Karen Messer, Daria A. Gaykalova, Joseph A. Califano, Mizuo Ando, Patrick K. Ha |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Science General Physics and Astronomy Datasets as Topic 02 engineering and technology Biology General Biochemistry Genetics and Molecular Biology Histones Proto-Oncogene Proteins c-myc 03 medical and health sciences Breast cancer Cancer epigenetics Cell Line Tumor Neoplasms Genetics Humans Gene Silencing lcsh:Science Head and neck cancer Cancer Multidisciplinary Transcription start General Chemistry DNA Methylation 021001 nanoscience & nanotechnology Publisher Correction CREB-Binding Protein Chromatin Colon cancer Gene Expression Regulation Neoplastic 030104 developmental biology Transcriptional repression DNA methylation Mutation lcsh:Q Transcription Initiation Site 0210 nano-technology E1A-Associated p300 Protein Signal Transduction |
| Zdroj: | Nature Communications Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019) Nature communications, vol 10, iss 1 |
| ISSN: | 2041-1723 |
| Popis: | Although promoter-associated CpG islands have been established as targets of DNA methylation changes in cancer, previous studies suggest that epigenetic dysregulation outside the promoter region may be more closely associated with transcriptional changes. Here we examine DNA methylation, chromatin marks, and transcriptional alterations to define the relationship between transcriptional modulation and spatial changes in chromatin structure. Using human papillomavirus-related oropharyngeal carcinoma as a model, we show aberrant enrichment of repressive H3K9me3 at the transcriptional start site (TSS) with methylation-associated, tumor-specific gene silencing. Further analysis identifies a hypermethylated subtype which shows a functional convergence on MYC targets and association with CREBBP/EP300 mutation. The tumor-specific shift to transcriptional repression associated with DNA methylation at TSSs was confirmed in multiple tumor types. Our data may show a common underlying epigenetic dysregulation in cancer associated with broad enrichment of repressive chromatin marks and aberrant DNA hypermethylation at TSSs in combination with MYC network activation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|