Lymphoblast biology and outcome among children with Down syndrome and ALL treated on CCG-1952
| Autor: | Paul S. Gaynon, James A. Whitlock, Harland Sather, Nyla A. Heerema, Linda C. Stork, Mylène Bassal, Mei K. La |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Oncology medicine.medical_specialty Down syndrome Aneuploidy Disease-Free Survival Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Child Ploidies business.industry Lymphoblast Infant Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma Prognosis medicine.disease Treatment Outcome Child Preschool Pediatrics Perinatology and Child Health Immunology Toxicity Cohort Hypodiploidy Female Hyperdiploidy Down Syndrome Trisomy business |
| Zdroj: | Pediatric Blood & Cancer. 44:21-28 |
| ISSN: | 1545-5017 1545-5009 |
| DOI: | 10.1002/pbc.20193 |
| Popis: | Background Patients with Down syndrome (DS) and standard risk (SR) acute lymphoblastic leukemia (ALL-DS) are reported to have inferior event free (EFS) and overall survival (OS) compared to patients without DS (ALL-NDS). Procedure We compared the prevalence of favorable and unfavorable clinical and biologic features, toxicity and outcome within the ALL-DS and ALL-NDS cohorts of 2,174 eligible patients with SR-ALL enrolled on CCG-1952. Results Fifty-nine patients (3%) had ALL-DS. DS patients were less likely to have either favorable (hyperdiploidy, triple trisomy of chromosomes 4, 10, and 17, TEL-AML1 rearrangement) or unfavorable (T-cell ALL, hypodiploidy, adverse translocations) biologic features. Toxicity occurred significantly more often and number of days hospitalized was significantly greater in ALL-DS than in ALL-NDS. ALL-DS patients had an inferior 4-year EFS compared to the NDS cohort. However, EFS was equivalent when the comparison excluded ALL-NDS with favorable biologic features. OS was significantly inferior for ALL-DS. Conclusions The absence of favorable biologic features within ALL-DS contributes to the difference in EFS previously observed between DS and NDS SR-ALL cohorts. © 2004 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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