Urinary 5-hydroxyindoleacetic acid and whole blood serotonin and tryptophan in autistic and normal subjects
| Autor: | Grard W. Akkerhuis, George M. Anderson, Ruud B. Minderaa, Fred R. Volkmar, Donald J. Cohen |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male Serotonin medicine.medical_specialty Adolescent Microgram Urinary system Biology Excretion chemistry.chemical_compound Internal medicine medicine Humans Autistic Disorder Biological Psychiatry Whole blood Creatinine 5-Hydroxyindoleacetic acid Tryptophan Hydroxyindoleacetic Acid Endocrinology chemistry Female medicine.drug |
| Zdroj: | Biological Psychiatry. 22:933-940 |
| ISSN: | 0006-3223 |
| DOI: | 10.1016/0006-3223(87)90002-3 |
| Popis: | Urinary 5-hydroxyindoleacetic acid (5-HIAA) excretion in two consecutive collection periods (5:00 PM-11:00 PM and 11:00 PM-8:00 AM) and whole blood serotonin (5-HT) and tryptophan (TRP) were measured in groups of unmedicated autistics (n = 16), medicated autistics (n = 20), and normal controls (n = 27). Whole blood 5-HT values were significantly higher in unmedicated autistics compared to normal controls. No significant differences were found in 5-HIAA excretion (microgram/mg creatinine, mean +/- SD) between unmedicated autistics (4.07 +/- 1.52) and normal controls (3.50 +/- 1.07), or between medicated (5.35 +/- 2.93) and drug-free autistic individuals. No correlations were found between 5-HT values and urinary 5-HIAA excretion. Urinary 5-HIAA (microgram/mg creatinine, mean +/- SD) was significantly greater in hyperserotonemic autistic subjects (4.88 +/- 0.87) compared to normal controls (3.50 +/- 1.07, total collection period; p = 0.002). The relevance of these findings to the possibility that increased gut production of 5-HT might cause the elevated whole blood 5-HT levels seen in autism is discussed. |
| Databáze: | OpenAIRE |
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