PD-1+ immune cell infiltration inversely correlates with survival of operable breast cancer patients

Autor: Jinglong Wang, David H. Garfield, Xiaochun Fei, Jianhua Wang, Xiumin Wang, Long Sun, Shenyou Sun, Qixiang Yu, Kunwei Shen, Ou Huang, Yan Mao, Fei Yuan, Xiaolong Jin
Rok vydání: 2014
Předmět:
Adult
Antigens
Differentiation
T-Lymphocyte
Oncology
Cancer Research
medicine.medical_specialty
medicine.medical_treatment
Breast surgery
Programmed Cell Death 1 Receptor
Immunology
Apoptosis
Breast Neoplasms
chemical and pharmacologic phenomena
Kaplan-Meier Estimate
CD8-Positive T-Lymphocytes
T-Lymphocytes
Regulatory
Disease-Free Survival
Lymphocytes
Tumor-Infiltrating
Breast cancer
Immune system
Cancer immunotherapy
Antigen
T-Lymphocyte Subsets
Internal medicine
medicine
Humans
Immunology and Allergy
Cytotoxic T cell
Lymphocyte Count
Mastectomy
Aged
Aged
80 and over
business.industry
Carcinoma
Ductal
Breast
FOXP3
Forkhead Transcription Factors
Middle Aged
Prognosis
medicine.disease
Combined Modality Therapy
Survival Analysis
Carcinoma
Lobular
Female
Radiotherapy
Adjuvant
business
CD8
Follow-Up Studies
T-Lymphocytes
Cytotoxic
Zdroj: Cancer Immunology, Immunotherapy. 63:395-406
ISSN: 1432-0851
0340-7004
DOI: 10.1007/s00262-014-1519-x
Popis: The programmed death-1 (PD-1) molecule is mainly expressed on functionally "exhausted" CD8(+) T cells, dampening the host antitumor immune response. We evaluated the ratio between effective and regulatory T cells (Tregs) and PD-1 expression as a prognostic factor for operable breast cancer patients. A series of 218 newly diagnosed invasive breast cancer patients who had undergone primary surgery at Ruijin Hospital were identified. The influence of CD8(+) cytotoxic T lymphocytes, FOXP3(+) (Treg cell marker), and PD-1(+) immune cell counts on prognosis was analyzed utilizing immunohistochemistry. Both PD-1(+) immune cells and FOXP3(+) Tregs counts were significantly associated with unfavorable prognostic factors. In bivariate, but not multivariate analysis, high tumor infiltrating PD-1(+) cell counts correlated with significantly shorter patient survival. Our results suggest a prognostic value of the PD-1(+) immune cell population in such breast cancer patients. Targeting the PD-1 pathway may be a feasible approach to treating patients with breast cancer.
Databáze: OpenAIRE
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