γ-Glutamyltaurine has potent and long-lasting antiepileptic action as demonstrated by intra-amygdaloid injection in amygdala-kindled rats
| Autor: | Shuji Uemura, Kazuharu Ienaga, Kunihiko Higashiura, Hiroshi Kimura |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Long lasting Taurine medicine.medical_specialty Time Factors Glutamine medicine.medical_treatment Amygdala Injections Rats Sprague-Dawley chemistry.chemical_compound Epilepsy Internal medicine Convulsion Kindling Neurologic medicine Animals Molecular Biology business.industry Kindling General Neuroscience Neuropeptides Generalized seizure medicine.disease Rats medicine.anatomical_structure Anticonvulsant Endocrinology chemistry Anticonvulsants Neurology (clinical) medicine.symptom business Developmental Biology |
| Zdroj: | Brain Research. 594:347-350 |
| ISSN: | 0006-8993 |
| Popis: | Intra-amygdaloid injections of gamma-glutamyltaurine, a recently identified brain dipeptide, strongly suppressed seizures in amygdala-kindled rats stimulated with intensities 10 or 50 microA above the generalized seizure triggering threshold (mean 82 microA). The suppressive effect persisted as long as 3 days. Taurine had relatively weak suppressive effects. Thus gamma-glutamyltaurine seems much more potent than taurine in the suppression of epileptic seizures when injected directly into the kindling site. |
| Databáze: | OpenAIRE |
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