A Molecularly Imprinted Sol-Gel Electrochemical Sensor for Naloxone Determination
| Autor: | Nora W. C. Chan, Narges Shaabani, Abebaw B Jemere |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Materials science
General Chemical Engineering 02 engineering and technology multiwall carbon nanotube 01 natural sciences Article lcsh:Chemistry sol-gel General Materials Science NLX nanomaterials Sol-gel Detection limit naloxone 010401 analytical chemistry Molecularly imprinted polymer 021001 nanoscience & nanotechnology 0104 chemical sciences Electrochemical gas sensor lcsh:QD1-999 electrochemical detection Electrode molecularly imprinted polymers 0210 nano-technology Selectivity Molecular imprinting Nuclear chemistry |
| Zdroj: | Nanomaterials Volume 11 Issue 3 Nanomaterials, Vol 11, Iss 631, p 631 (2021) |
| ISSN: | 2079-4991 |
| DOI: | 10.3390/nano11030631 |
| Popis: | A molecularly imprinted sol-gel is reported for selective and sensitive electrochemical determination of the drug naloxone (NLX). The sensor was developed by combining molecular imprinting and sol-gel techniques and electrochemically grafting the sol solution onto a functionalized multiwall carbon nanotube modified indium-tin oxide (ITO) electrode. The sol-gel layer was obtained from acid catalyzed hydrolysis and condensation of a solution composed of triethoxyphenylsilane (TEPS) and tetraethoxysilane (TES). The fabrication, structure and properties of the sensing material were characterized via scanning electron microscopy, spectroscopy and electrochemical techniques. Parameters affecting the sensor’s performance were evaluated and optimized. A sensor fabricated under the optimized conditions responded linearly between 0.0 µM and 12 µM NLX, with a detection limit of 0.02 µM. The sensor also showed good run-to-run repeatability and batch-to-batch performance reproducibility with relative standard deviations (RSD) of 2.5–7.8% (n = 3) and 9.2% (n = 4), respectively. The developed sensor displayed excellent selectivity towards NLX compared to structurally similar compounds (codeine, fentanyl, naltrexone and noroxymorphone), and was successfully used to measure NLX in synthetic urine samples yielding recoveries greater than 88%. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|