A 59-kd Renal Antigen as a New Target for Rapidly Progressive Glomerulonephritis
| Autor: | Laure Hélène Noël, Thomas Hellmark, Khalil El Karoui, Agathe Pardon, Vincent Audard, Philippe Remy, Dominique Desvaux, Guy Touchard, Philippe Lang, Djillali Sahali |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Pathology
medicine.medical_specialty Anti-Glomerular Basement Membrane Disease urologic and male genital diseases Autoantigens Methylprednisolone Antigen medicine Humans Rapidly progressive glomerulonephritis Goodpasture syndrome Direct fluorescent antibody Basement membrane biology urogenital system business.industry Glomerulonephritis Middle Aged medicine.disease female genital diseases and pregnancy complications Staining Kidney Tubules medicine.anatomical_structure Nephrology Immunology Disease Progression biology.protein Female Antibody business |
| Zdroj: | American Journal of Kidney Diseases. 49:710-716 |
| ISSN: | 0272-6386 |
| DOI: | 10.1053/j.ajkd.2007.02.002 |
| Popis: | Anti-glomerular basement membrane (anti-GBM) antibodies are the hallmark of anti-GBM disease, which is characterized by rapidly progressive glomerulonephritis. We describe the case of a 58-year-old woman who presented with rapidly progressive glomerulonephritis with typical anti-GBM staining found by means of direct immunofluorescence microscopy, associated with linear immunoglobin G deposits on tubules. Serum analysis showed circulating anti-tubular basement membrane antibodies, but failed to detect anti-GBM antibodies. Immunoblotting showed that serum antibodies reacted with a 59-kd antigen found along both the GBM and tubular basement membrane. |
| Databáze: | OpenAIRE |
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