Effect of varying concentrations of linoleic acid on α-adrenoceptor responses in spontaneously hypertensive rats
| Autor: | Brian M. Goldstein, Florence H. Lizzo, Peter Cervoni, David L. Crandall, Robert J. Lozito |
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| Rok vydání: | 1988 |
| Předmět: |
Male
Agonist medicine.medical_specialty medicine.drug_class Linoleic acid Clinical Biochemistry Adrenergic Linoleic Acid chemistry.chemical_compound Rats Inbred SHR Internal medicine Heart rate medicine Animals Receptor Sarcolemma Hemodynamics Cell Biology Receptors Adrenergic alpha Rats Blood pressure Endocrinology Linoleic Acids chemistry Hypertension Fatty Acids Unsaturated Norepinephrine Bitartrate |
| Zdroj: | Prostaglandins, Leukotrienes and Essential Fatty Acids. 33:115-119 |
| ISSN: | 0952-3278 |
| DOI: | 10.1016/0952-3278(88)90150-0 |
| Popis: | The effect of increased intake of linoleic acid on the alpha-adrenergic system was assessed by safflower oil supplementation to spontaneously hypertensive rats. Linoleic acid-enriched intake at 5%, 15% and 30% by weight of total food intake for 12 wk was associated with a reduction in resting arterial blood pressure, while heart rate and heart to body weight ratios were similar to control group values. A dose-response analysis to norepinephrine bitartrate administered intravenously indicated a significant reduction in the vascular reactivity to this alpha-adrenergic agonist in all groups given linoleic acid. Direct assessment of alpha-adrenoceptor number (Bmax) and affinity (KD) in cardiac sarcolemma with [3H]-prazosin indicated that receptor binding properties were not affected by linoleic acid intake. Our results suggest that short-term linoleic acid supplementation in the established hypertensive state may lower blood pressure through effects upon alpha-adrenergic reactivity in vascular tissue, without associated effects in cardiac tissue. |
| Databáze: | OpenAIRE |
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