Optical Coherence Tomography Angiography Compared with Multimodal Imaging for Diagnosing Neovascular Central Serous Chorioretinopathy
| Autor: | Shaheeda Mohamed, Fanny Yip, Linbin Zhou, Chi Pui Pang, Danny Siu-Chun Ng, Wee Min Teh, Mary Ho, Marten E. Brelen, Timothy Y Y Lai, Li Jia Chen, Haoyu Chen, Chi Wai Tsang |
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| Rok vydání: | 2021 |
| Předmět: |
Indocyanine Green
medicine.medical_specialty genetic structures Multimodal Imaging 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ophthalmology medicine Humans Prospective Studies Fluorescein Angiography Retrospective Studies 030304 developmental biology 0303 health sciences medicine.diagnostic_test Receiver operating characteristic Choroid business.industry Fundus photography Retinal Fluorescein angiography Choroidal Neovascularization eye diseases Confidence interval Serous fluid Cross-Sectional Studies Choroidal neovascularization Central Serous Chorioretinopathy chemistry Angiography 030221 ophthalmology & optometry sense organs medicine.symptom business Tomography Optical Coherence |
| Zdroj: | American Journal of Ophthalmology. 232:70-82 |
| ISSN: | 0002-9394 |
| DOI: | 10.1016/j.ajo.2021.05.029 |
| Popis: | PURPOSE To assess the diagnostic accuracy of optical coherence tomography angiography (OCTA) compared with multimodal imaging for choroidal neovascularization (CNV) in central serous chorioretinopathy (CSC) eyes and to determine the features that predicted CNV. DESIGN Prospective cross-sectional study. METHODS Consecutive CSC patients were recruited from retina clinic. The reference standard for CNV was determined by interpretation of multimodal imaging with OCTA, structural OCT line scan, fluorescein angiography (FA), indocyanine green angiography (ICGA), ultra-widefield fundus photography and fundus autofluorescence (FAF). Two independent masked graders examined OCTA without FA and ICGA to diagnose CNV. Univariate and multivariate analyses were performed to evaluate factors associated with CNV. RESULTS CNV was detected in 69 eyes in 64 out of 277 CSC patients according to reference standard. The two masked graders who examined OCTA had sensitivity of 81.2% (95% Confidence Interval [CI], 71.9%-90.4%) and 78.3% (95% CI, 68.5%-88.0%), specificity of 97.3% (95% CI, 95.9%-98.8%) and 96.2% (95% CI, 94.5%-98.0%), positive predictive values of 82.4% (95% CI, 73.3%-91.4%) and 76.1% (95% CI, 66.1%-86.0%), and negative predictive values of 97.1% (95% CI, 95.6%-98.7%) and 96.7% (95% CI, 95.0%-98.3%). Their mean area under the receiver operating characteristic curve (AUC) was 0.88 with good agreement (Kappa coefficient 0.80 [95% CI, 0.72-0.89]). Flat irregular pigment epithelial detachment on structural OCT, neovascular network on OCTA and ill-defined late leakage on FA significantly correlated with CNV in CSC from multiple regression (P CONCLUSIONS There is discordance between OCTA and multimodal imaging in diagnosing CNV in CSC. This study demonstrated the caveats in OCTA interpretation, such as small extrafoveal lesions and retinal pigment epithelial alterations. Comprehensive interpretation of OCTA with dye angiography and structural OCT is recommended. |
| Databáze: | OpenAIRE |
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