A genetically female brain is required for a regular reproductive cycle in chicken brain chimeras
| Autor: | Jun-ichi Shiraishi, Miyano Sakurai, Shizuko Murakami, Masaoki Tsudzuki, Ken Ohara, Teruo Maeda, Kazuyoshi Tsutsui, Kazutoshi Yamamoto, Ryo Tadano, Hidefumi Yoshioka, Takashi Bungo, Shogo Haraguchi, Kohei Tomonari, Hiroko Ohki-Hamazaki, Takao Oka, Kohichi Tanaka, Tatsuhiko Goto, Fumihiko Maekawa, Yuki Yamashita |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Ovulation medicine.medical_specialty Sex Differentiation media_common.quotation_subject General Physics and Astronomy Chick Embryo Biology General Biochemistry Genetics and Molecular Biology Semen Internal medicine medicine Animals Sexual maturity Sexual Maturation Gonadal Steroid Hormones media_common Neurons Estrous cycle Neurotransmitter Agents Sex Characteristics Multidisciplinary Sexual differentiation Behavior Animal Estradiol Chimera Reproduction Brain General Chemistry Luteinizing Hormone Spermatozoa Endocrinology Female Development of the gonads Luteinizing hormone Chickens Sex characteristics Hormone |
| Zdroj: | Nature Communications. 4 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/ncomms2372 |
| Popis: | Sexual differentiation leads to structural and behavioural differences between males and females. Here we investigate the intrinsic sex identity of the brain by constructing chicken chimeras in which the brain primordium is switched between male and female identities before gonadal development. We find that the female chimeras with male brains display delayed sexual maturation and irregular oviposition cycles, although their behaviour, plasma concentrations of sex steroids and luteinizing hormone levels are normal. The male chimeras with female brains show phenotypes similar to typical cocks. In the perinatal period, oestrogen concentrations in the genetically male brain are higher than those in the genetically female brain. Our study demonstrates that male brain cells retain male sex identity and do not differentiate into female cells to drive the normal oestrous cycle, even when situated in the female hormonal milieu. This is clear evidence for a sex-specific feature that develops independent of gonadal steroids. |
| Databáze: | OpenAIRE |
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