Parasternal intercostal muscle ultrasound in chronic obstructive pulmonary disease correlates with spirometric severity
| Autor: | Louis Irving, Selina M Parry, Candice Law, Sourav Das, Daniel P Steinfort, Mark Hew, Peter Wallbridge, Gary Hammerschlag |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Spirometry Quadriceps Thickness medicine.medical_specialty Chronic Obstructive Pulmonary Disease Science Diaphragm Intercostal Muscles Severity of Illness Index Article Pulmonary Disease Chronic Obstructive Muscle Quantity 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans 030212 general & internal medicine Respiratory system Aged Ultrasonography Parasternal Intercostals Multidisciplinary Lung medicine.diagnostic_test Electromyography business.industry Ultrasound Echogenicity Diaphragm Thickness Middle Aged Respiratory Function Tests Diaphragm (structural system) medicine.anatomical_structure 030228 respiratory system Parasternal line Cardiology Medicine Female Tomography X-Ray Computed business Intercostal muscle |
| Zdroj: | Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-018-33666-7 |
| Popis: | In chronic obstructive pulmonary disease (COPD), loss of computed tomography (CT)-measured intercostal mass correlates with spirometric severity. Intercostal muscle ultrasound offers a repeatable and radiation-free alternative, however requires validation. We aimed to determine the reliability of parasternal intercostal muscle ultrasound, and the concurrent validity of parasternal ultrasound with clinicometric parameters. Twenty stable COPD patients underwent ultrasound measurement of thickness and echogenicity of 2nd and 3rd parasternal intercostal muscles, dominant pectoralis major and quadriceps, and diaphragm thickness; spirometry; and chest CT. Intra-rater intraclass correlation (ICC) for ultrasound intercostal thickness was 0.87–0.97 depending on site, with echogenicity ICC 0.63–0.91. Inter-rater ICC was fair to excellent. Ultrasound intercostal thickness moderately correlated with FEV1% predicted (r = 0.33) and quadriceps thickness (r = 0.31). Echogenicity correlated negatively with FEV1% predicted (r = −0.32). CT-measured lateral intercostal mass correlate negatively with parasternal ultrasound intercostal thickness. These data confirm ultrasound of parasternal intercostal musculature is reproducible. Lower intercostal muscle quantity and quality reflects greater COPD spirometric severity. This novel tool may have biomarker potential for both the systemic effects of COPD on muscle as well as local disruption of respiratory mechanics. The negative correlation between CT and ultrasound measurements may reflect complex site-dependent interactions between respiratory muscles and the chest wall. |
| Databáze: | OpenAIRE |
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