Overexpression of S100A4 is closely related to the aggressiveness of gastric cancer
| Autor: | Young Sil Kim, Nam Jin Yoo, Jong Woo Lee, Hong Sug Kim, Chang Jae Kim, Yong Gu Cho, Jong Heun Lee, Sug Hyung Lee, Suk Woo Nam, Cho Hyun Park, Jung Young Lee, Jik Young Park, Tae Yon Kim, Young Hwa Song, Won Park |
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| Rok vydání: | 2003 |
| Předmět: |
Microbiology (medical)
Pathology medicine.medical_specialty DNA Mutational Analysis Gene Expression Single-nucleotide polymorphism Adenocarcinoma Gene mutation Biology medicine.disease_cause Polymorphism Single Nucleotide Pathology and Forensic Medicine Metastasis Stomach Neoplasms Tumor Cells Cultured medicine Humans Immunology and Allergy Neoplasm Invasiveness S100 Calcium-Binding Protein A4 Stomach cancer Polymorphism Single-Stranded Conformational Mammary tumor Mutation Korea Base Sequence S100 Proteins digestive oral and skin physiology Cancer DNA Neoplasm General Medicine Prognosis medicine.disease Immunohistochemistry digestive system diseases |
| Zdroj: | APMIS. 111:539-545 |
| ISSN: | 1600-0463 0903-4641 |
| Popis: | Elevated levels of the calcium-binding protein S100A4 cause metastasis of benign rat mammary tumor cells. To investigate whether S100A4 plays an important role in the invasion and metastasis of gastric cancers, we examined the gene mutations in the coding regions and expression patterns of the S100A4 in gastric adenocarcinoma in Korea. Moderate to strong expression of S100A4 was found in 53 (68.8%) of the 77 gastric adenocarcinomas, whilst normal gastric epithelium either failed to stain or showed weak staining. Interestingly, S100A4 expression was more frequently observed in gastric cancer patients with advanced gastric cancer (p=0.039), positive lymph node metastasis (p=0.001), and peritoneal dissemination (p=0.022). No gene mutations were found in the analyzed genomic area in 77 gastric adenocarcinomas and 15 gastric cancer cell lines. We found one single nucleotide polymorphism without an amino acid change, A99G, in two cases. These data suggest that the overexpression of S100A4 may be closely related to the aggressiveness of gastric cancer in Korea. |
| Databáze: | OpenAIRE |
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