Alternative carbohydrate pathways – enzymes, functions and engineering

Autor:	Anwar Sunna, Dominik Kopp
Rok vydání:	2020
Předmět:	chemistry.chemical_classification Carbon metabolism Bacteria Cell-Free System biology Chemistry General Medicine Carbohydrate Central carbon metabolism Applied Microbiology and Biotechnology Cofactor Metabolic engineering Enzyme Metabolic Engineering Biochemistry biology.protein Carbohydrate Metabolism Thermodynamics Embden-Meyerhof-Parnas pathway Entner–Doudoroff pathway Metabolic Networks and Pathways Biotechnology
Zdroj:	Critical Reviews in Biotechnology. 40:895-912
ISSN:	1549-7801 0738-8551
DOI:	10.1080/07388551.2020.1785386
Popis:	Metabolic engineering is crucial in the development of production strains for platform chemicals, pharmaceuticals and biomaterials from renewable resources. The central carbon metabolism (CCM) of heterotrophs plays an essential role in the conversion of biomass to the cellular building blocks required for growth. Yet, engineering the CCM ultimately aims toward a maximization of flux toward products of interest. The most abundant dissimilative carbohydrate pathways amongst prokaryotes (and eukaryotes) are the Embden-Meyerhof-Parnas (EMP) and the Entner-Doudoroff (ED) pathways, which build the basics for heterotrophic metabolic chassis strains. Although the EMP is regarded as the textbook example of a carbohydrate pathway owing to its central role in production strains like
Databáze:	OpenAIRE
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