Decellularized Caprine Conchal Cartilage toward Repair and Regeneration of Damaged Cartilage
| Autor: | Samit Kumar Nandi, Rupnarayan Bhattacharya, Piyali Das, Yogendra Pratap Singh, Bikash Kanti Biswas, Siddhartha Narayan Joardar, Biman B. Mandal |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Auricular cartilage
Reconstructive surgery medicine.medical_specialty Decellularization genetic structures business.industry Regeneration (biology) Cartilage Biochemistry (medical) Biomedical Engineering General Chemistry Conchal cartilage Surgery Biomaterials stomatognathic diseases medicine.anatomical_structure otorhinolaryngologic diseases medicine business human activities |
| Zdroj: | ACS Applied Bio Materials. 2:2037-2049 |
| ISSN: | 2576-6422 |
| DOI: | 10.1021/acsabm.9b00078 |
| Popis: | Repair and regeneration of nasal and auricular cartilage thrust significant challenges in reconstructive surgery. The burgeoning clinical requirement is yet to endorse a satisfactory cartilage replacement matrix. In this regard, we have bioengineered cross-linked decellularized caprine conchal cartilage (DC) as biocompatible, durable, and nontoxic matrices. The DC matrices exhibited reduced DNA and sulfated glycosaminoglycan (sGAG) with a minimal effect on the collagen content. Further, histology and scanning electron micrographs revealed a significant loss of cellular bodies and the presence of a compact matrix consisting of intricate collagen fibers, when compared to unprocessed matrices. An |
| Databáze: | OpenAIRE |
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