Decrease of Intrathyroidal CD161+V.ALPHA.24+V.BETA.11+ NKT Cells in Graves' disease
| Autor: | Fumio Matsuzuka, Akira Miyauchi, Yuuki Takamura, Yukiyo Nakamura, Mikio Watanabe, Yoshinori Iwatani |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Receptors Antigen T-Cell alpha-beta Endocrinology Diabetes and Metabolism Graves' disease Thyroid Gland Down-Regulation medicine.disease_cause Flow cytometry Autoimmunity Endocrinology Internal medicine medicine Humans Lectins C-Type Lymphocyte Count medicine.diagnostic_test business.industry T-cell receptor Thyroid Middle Aged Natural killer T cell medicine.disease Graves Disease Peripheral Killer Cells Natural medicine.anatomical_structure Case-Control Studies Antigens Surface T cell subset Immunology Female business NK Cell Lectin-Like Receptor Subfamily B |
| Zdroj: | Endocrine Journal. 55:199-203 |
| ISSN: | 1348-4540 0918-8959 |
| DOI: | 10.1507/endocrj.k07e-006 |
| Popis: | To clarify changes in the intrathyroidal natural killer T (NKT) cell subset, which prevents autoimmunity in patients with Graves' disease (GD), we examined intrathyroidal and peripheral lymphocytes in 11 patients with GD and peripheral lymphocytes in nine healthy volunteers using three-color flow cytometry. The proportion of CD161 (+) T cell receptor Valpha24 (+) Vbeta11 (+) cells, which represent the NKT cell subset, was lower in the thyroid of patients with GD than in the peripheral blood of the same patients and in the peripheral blood of healthy subjects. These results indicate that the proportion of intrathyroidal NKT cells is decreased in patients with GD and that this decrease may contribute to incomplete regulation of autoreactive T cells in GD. |
| Databáze: | OpenAIRE |
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