| Autor: |
Andreas Buchmann, Vladimir S. Kostic, Amanda Aerni, Katharina Henke, Jürgen Hänggi, K-D Huynh, Hanna Kaduszkiewicz, Leo Gschwind, Christian R.A. Mondadori, Elka Stefanova, Christian Vogler, J. C. Sigmund, Ivana Novakovic, B. Wiese, SG Riedel-Heller, Daniel Coluccia, Horst Bickel, Martin Dichgans, A Müller, S. Weyerer, H. van den Bussche, Frank Jessen, Andreas Papassotiropoulos, Michael Pentzek, Wolfgang Maier, Philippe Demougin, Michael Wagner, D J-F de Quervain |
| Přispěvatelé: |
University of Zurich, Papassotiropoulos, A |
| Jazyk: |
angličtina |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
Molecular Psychiatry |
| ISSN: |
1476-5578
1359-4184 |
| Popis: |
Recent advances in the development of high-throughput genotyping platforms allow for the unbiased identification of genes and genomic sequences related to heritable traits. In this study, we analyzed human short-term memory, which refers to the ability to remember information over a brief period of time and which has been found disturbed in many neuropsychiatric conditions, including schizophrenia and depression. We performed a genome-wide survey at 909 622 polymorphic loci and report six genetic variations significantly associated with human short-term memory performance after genome-wide correction for multiple comparisons. A polymorphism within SCN1A (encoding the alpha subunit of the type I voltage-gated sodium channel) was replicated in three independent populations of 1699 individuals. Functional magnetic resonance imaging during an n-back working memory task detected SCN1A allele-dependent activation differences in brain regions typically involved in working memory processes. These results suggest an important role for SCN1A in human short-term memory. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
