The effects of single dose of methamphetamine on lipid peroxidation levels in the rat striatum and prefrontal cortex
| Autor: | Berkant Muammer Kayatekin, Osman Açikgöz, Nazan Uysal, Cetin Pekcetin, Ayfer Dayi, Ataman Güre, Sevil Gönenç, İlgi Şemin |
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| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Prefrontal Cortex Striatum medicine.disease_cause Thiobarbituric Acid Reactive Substances Methamphetamine Lipid peroxidation chemistry.chemical_compound Dopamine Internal medicine medicine Animals Pharmacology (medical) Rats Wistar Prefrontal cortex Biological Psychiatry Pharmacology Glutathione Peroxidase Dose-Response Relationship Drug Superoxide Dismutase Dopaminergic Neurotoxicity medicine.disease Corpus Striatum Rats Oxidative Stress Psychiatry and Mental health Endocrinology Neurology chemistry Lipid Peroxidation Neurology (clinical) Neuroscience Oxidative stress medicine.drug |
| Zdroj: | European Neuropsychopharmacology. 10:415-418 |
| ISSN: | 0924-977X |
| DOI: | 10.1016/s0924-977x(00)00103-6 |
| Popis: | The administration of methamphetamine to experimental animals results in damage to dopaminergic neurons. In the present study, we demonstrated that a single dose (15 mg/kg) of methamphetamine results in production of oxidative stress as demonstrated by increased thiobarbituric acid reactive substances levels in the rat striatum and prefrontal cortex. In conclusion, the results of present study provide further evidence in support of the notion that oxidative stress may play an important role in the methamphetamine-induced neurotoxicity. (C) 2000 Elsevier Science BN. All rights reserved. |
| Databáze: | OpenAIRE |
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