Sleep modulates hematopoiesis and protects against atherosclerosis

Autor: Peter Libby, Vanessa Frodermann, Friedrich Felix Hoyer, Christoph J. Binder, Christopher T. Chan, Annemijn F. Gregory, Yoshiko Iwamoto, Anne Vassalli, Cameron S. McAlpine, Matthias Nahrendorf, Atsushi Anzai, Filip K. Swirski, Thomas E. Scammell, Shun He, Florian Kahles, Wolfram C. Poller, Ashley M. Fenn, Mehdi Tafti, John E. Mindur, Colin Valet, Sara Rattik, Lennard Halle, M. Kiss
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
0301 basic medicine
medicine.medical_specialty
Lateral hypothalamus
Neutrophils
Bone Marrow Cells
Monocytes
Article
Mice
03 medical and health sciences
0302 clinical medicine
Monocytosis
Orexin Receptors
Internal medicine
mental disorders
medicine
Animals
Antigens
Ly
Antigens
Ly/metabolism
Atherosclerosis/metabolism
Atherosclerosis/pathology
Atherosclerosis/prevention & control
Bone Marrow Cells/metabolism
Female
Hematopoiesis/drug effects
Hematopoiesis/physiology
Hypothalamic Area
Lateral/metabolism
Monocytes/drug effects
Monocytes/metabolism
Myelopoiesis/drug effects
Neutrophils/metabolism
Orexin Receptors/deficiency
Orexin Receptors/metabolism
Orexins/biosynthesis
Orexins/deficiency
Orexins/metabolism
Orexins/pharmacology
Sleep/drug effects
Sleep/physiology
Sleep Deprivation/metabolism
Sleep Deprivation/physiopathology
Sleep Deprivation/prevention & control
Fragmentation (cell biology)
Pathological
Myelopoiesis
Orexins
Multidisciplinary
business.industry
Macrophage Colony-Stimulating Factor
Atherosclerosis
medicine.disease
Sleep in non-human animals
Hematopoiesis
3. Good health
Haematopoiesis
030104 developmental biology
Endocrinology
medicine.anatomical_structure
nervous system
Hypothalamic Area
Lateral
Sleep Deprivation
Bone marrow
Sleep
business
psychological phenomena and processes
030217 neurology & neurosurgery
Zdroj: Nature
Nature, vol. 566, no. 7744, pp. 383-387
ISSN: 1476-4687
0028-0836
Popis: Sleep is integral to life 1 . Although insufficient or disrupted sleep increases the risk of multiple pathological conditions, including cardiovascular disease 2 , we know little about the cellular and molecular mechanisms by which sleep maintains cardiovascular health. Here we report that sleep regulates haematopoiesis and protects against atherosclerosis in mice. We show that mice subjected to sleep fragmentation produce more Ly-6C high monocytes, develop larger atherosclerotic lesions and produce less hypocretin-a stimulatory and wake-promoting neuropeptide-in the lateral hypothalamus. Hypocretin controls myelopoiesis by restricting the production of CSF1 by hypocretin-receptor-expressing pre-neutrophils in the bone marrow. Whereas hypocretin-null and haematopoietic hypocretin-receptor-null mice develop monocytosis and accelerated atherosclerosis, sleep-fragmented mice with either haematopoietic CSF1 deficiency or hypocretin supplementation have reduced numbers of circulating monocytes and smaller atherosclerotic lesions. Together, these results identify a neuro-immune axis that links sleep to haematopoiesis and atherosclerosis.
Databáze: OpenAIRE
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