Phytol, a Chlorophyll Component, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects: Possible NFκB Pathway Involvement and Reduced Levels of the Proinflammatory Cytokines TNF-α and IL-6
| Autor: | Fabrício Santana Oliveira, Angelo R. Antoniolli, Laurent Picot, Irwin Rose Alencar de Menezes, Luana Heimfarth, Lucindo José Quintans-Júnior, Alexandra M.S. Carvalho, Jullyana S.S. Quintans, Henrique Douglas Melo Coutinho, Erik Willyame Menezes Pereira |
|---|---|
| Přispěvatelé: | LIttoral ENvironnement et Sociétés - UMRi 7266 (LIENSs), Université de La Rochelle (ULR)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Chlorophyll
Freund's Adjuvant Anti-Inflammatory Agents Pharmaceutical Science Arthritis Pain Pharmacology 01 natural sciences Analytical Chemistry Proinflammatory cytokine Phytol chemistry.chemical_compound Mice [SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication Drug Discovery medicine Synovial fluid Animals Edema [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM] ComputingMilieux_MISCELLANEOUS Inflammation Antiarthritic agent Molecular Structure 010405 organic chemistry Interleukin-6 Tumor Necrosis Factor-alpha Organic Chemistry Synovial Membrane NF-kappa B medicine.disease 3. Good health 0104 chemical sciences 010404 medicinal & biomolecular chemistry Disease Models Animal medicine.anatomical_structure Complementary and alternative medicine chemistry Hyperalgesia Molecular Medicine Cytokines Synovial membrane Diterpene medicine.symptom |
| Zdroj: | Journal of Natural Products Journal of Natural Products, American Chemical Society, 2020, 83 (4), pp.1107-1117. ⟨10.1021/acs.jnatprod.9b01116⟩ |
| ISSN: | 0163-3864 1520-6025 |
| DOI: | 10.1021/acs.jnatprod.9b01116⟩ |
| Popis: | Phytol is a diterpene constituent of chlorophyll and has been shown to have several pharmacological properties, particularly in relation to the management of painful inflammatory diseases. Arthritis is one of the most common of these inflammatory diseases, mainly affecting the synovial membrane, cartilage, and bone in joints. Proinflammatory cytokines, such as TNF-α and IL-6, and the NFκB signaling pathway play a pivotal role in arthritis. However, as the mechanisms of action of phytol and its ability to reduce the levels of these cytokines are poorly understood, we decided to investigate its pharmacological effects using a mouse model of complete Freund's adjuvant (CFA)-induced arthritis. Our results showed that phytol was able to inhibit joint swelling and hyperalgesia throughout the whole treatment period. Moreover, phytol reduced myeloperoxidase (MPO) activity and proinflammatory cytokine release in synovial fluid and decreased IL-6 production as well as the COX-2 immunocontent in the spinal cord. It also downregulated the p38MAPK and NFκB signaling pathways. Therefore, our findings demonstrated that phytol can be an innovative antiarthritic agent due to its capacity to attenuate inflammatory reactions in joints and the spinal cord, mainly through the modulation of mediators that are key to the establishment of arthritic pain. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|