Montelukast, current indications and prospective future applications
| Autor: | Nidal Jaradat, Suhaib Hattab, Azza Ziyadeh-Isleem, Naim Kittana, Abdel-Naser Zaid |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pulmonary and Respiratory Medicine
Cyclopropanes medicine.medical_specialty Acetates Sulfides Anti-asthmatic Agent Bronchospasm law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial immune system diseases law Adrenal Cortex Hormones medicine Immunology and Allergy Humans Anti-Asthmatic Agents Intensive care medicine Montelukast Asthma business.industry Therapeutic effect Public Health Environmental and Occupational Health medicine.disease respiratory tract diseases Clinical trial Asthma Exercise-Induced 030228 respiratory system Anesthesia Pharmacogenomics Quinolines Leukotriene Antagonists medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Expert review of respiratory medicine. 10(9) |
| ISSN: | 1747-6356 |
| Popis: | Montelukast is recommended for the treatment of asthma, exercise -induced bronchospasm and allergic rhinitis. Several trials demonstrated potential therapeutic effects in other respiratory conditions, and different animal-model-based studies explored potential pharmacological actions in non-respiratory conditions.Clinical investigations on the pharmacotherapeutic effects of montelukast, in addition to in-vivo studies on animal models of non-respiratory diseases. The data discussed in this review were mainly obtained from clinical randomized trials, real-life studies, and studies based on animal models as approve of concept. As a condition, all of the discussed articles were published in journals cited by Pubmed. Expert commentary: The current clinical data are in favor of montelukast use in the management of chronic asthma as an add-on or alternative therapy to the inhaled corticosteroids. Further clinical trials are required to confirm the effectiveness and feasibility of montelukast for the treatment of conditions other than the current clinical indications. |
| Databáze: | OpenAIRE |
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