Extranodal NK/T Cell Lymphoma, Nasal Type with Palatal Involvement: A Rare Case Report and Literature Review
| Autor: | Grigorios Thermos, Alexandra Sklavounou-Andrikopoulou, Anastasia Andreou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Pathology Palatine Tonsil Case Reports Extranodal NK/T-cell lymphoma nasal type Palatine tonsil Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Biopsy medicine T-cell lymphoma Humans Aged medicine.diagnostic_test Soft palate business.industry Combination chemotherapy medicine.disease Lymphoma Lymphoma Extranodal NK-T-Cell 030104 developmental biology medicine.anatomical_structure Oncology Otorhinolaryngology 030220 oncology & carcinogenesis Histopathology Palate Soft business |
| Zdroj: | Head Neck Pathol |
| Popis: | T-cell lymphomas are infrequently encountered in the head and neck area, with the most common subtype being Extranodal NK/T cell lymphoma, nasal type (ENKTL-NT). ENKTL-NT shows a predilection for midline facial structures presenting with ulcerative destructive lesions, whereas palatal involvement is one of the most prominent signs from the oral cavity. Herein, we describe a case of a 76-year-old Greek man with nasal obstruction and an extensive painful necrotic ulcer with ragged borders on the left distal portion of the soft palate and palatine tonsil of 4-months duration. After an initial non-diagnostic biopsy from the nasopharynx, a second incisional biopsy from the palatal lesions was performed. Histopathology was suggestive of an angiocentric lymphoproliferative neoplasm and immunohistochemical examination and in situ hybridization for EBV RNA led to a final diagnosis of ENKTL-NT. The patient was placed under combined chemotherapy and radiotherapy and no recurrence has been noted. Additionally, a retrospective review of the cases in the English literature with an established diagnosis of ENTKL-NT between 2000 and 2019, based on the latest WHO classification of Head and Neck tumors, is performed. |
| Databáze: | OpenAIRE |
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